Disease Mapping with WinBUGS and MLwiN (eBook)

Andrew B. Lawson is a professor of biostatistics and eminent scholar in the Division of Biostatistics and Epidemiology in the College of Medicine at the Medical University of South Carolina. He is an ASA fellow and an advisor in disease mapping and risk assessment for the World Health Organization. Dr. Lawson has published over 100 journal papers and eight books and is the founding editor of Spatial and Spatio-temporal Epidemiology. He received a PhD in spatial statistics from the University of St. Andrews. His research interests include the analysis of clustered disease maps, spatial and spatio-temporal disease surveillance, nutritional measurement error, and Bayesian latent variable and SEM modeling.

Preface.

Notation.

0.1 Standard notation for multilevel modelling.

0.2 Spatial multiple-membership models and the MMMC
notation.

0.3 Standard notation for WinBUGS models.

1. Disease mapping basics.

1.1 Disease mapping and map reconstruction.

1.2 Disease map restoration.

2. Bayesian hierarchical modelling.

2.1 Likelihood and posterior distributions.

2.2 Hierarchical models.

2.3 Posterior inference.

2.4 Markov chain Monte Carlo methods.

2.5 Metropolis and Metropolis-Hastings algorithms.

2.6 Residuals and goodness of fit.

3. Multilevel modelling.

3.1 Continuous response models.

3.2 Estimation procedures for multilevel models.

3.3 Poisson response models.

3.4 Incorporating spatial information.

3.5 Discussion.

4. WinBUGS basics.

4.1 About WinBUGS.

4.2 Start using WinBUGS.

4.3 Specification of the model.

4.4 Model fitting.

4.5 Scripts.

4.6 Checking convergence.

4.7 Spatial modelling: GeoBUGS.

4 .8 Conclusions.

5. MLwiN basics.

5.1 About MLwiN.

5.2 Getting started.

5.3 Fitting statistical models.

5.4 MCMC estimation in MLwiN.

5.5 Spatial modelling.

5.6 Conclusions.

6. Relative risk estimation.

6.1 Relative risk estimation using WinBUGS.

6.2 Spatial prediction.

6.3 An analysis of the Ohio dataset using MLwiN.

7. Focused clustering: the analysis of putative health
hazards.

7.1 Introduction.

7.2 Study design.

7.3 Problems of inference.

7.4 Modelling the hazard exposure risk.

7.5 Models for count data.

7.6 Bayesian models.

7.7 Focused clustering in WinBUGS.

7.8 Focused clustering in MLwiN.

8. Ecological analysis.

8.1 Introduction.

8.2 Statistical models.

8.3 WinBUGS analyses of ecological datasets.

8.4 MLwiN analyses of ecological datasets.

9. Spatially-correlated survival analysis.

9.1 Survival analysis in WinBUGS.

9.2 Survival analysis in MLwiN.

10. Epilogue.

Appendix 1: WinBUGS code for focused clustering models.

A.1: Falkirk example.

A.2: Ohio example.

Appendix 2: S-Plus function for conversion to GeoBUGS
format.

Bibliography.

Index.

"...written at a level that will be readily accessible to
anyone with a modest background in applied statistics."
(Technometrics, February 2005)

"The book certainly is a nice addition to my disease mapping
books. The book is equally useful for the undergraduate and
graduate students as well as public health professionals.
(E-STREAMS, July 2004)

"...a good guide and a useful addition for any
graduate statistician or epidemiologist..."
(Statistical Methods in Medical Research, No.13 2004)

"...outlines the models used in statistical disease mapping, and
gives details of how the models can be implemented using two
packages..." (Short Book Reviews, Vol.24, No.3)

"Readers... will greatly profit from this book"
(International Society of Clinical Biostatistics Dec
2005)