Food Additives and Hyperactive Children

1 Background of the Problem.- Childhood Behavior and Learning Problems.- Dr. Feingold's Hypothesis.- Clinical Studies of the Feingold Diet.- Clinical Case Trials.- 2 Controlled Diet Trials.- Design of the First Controlled Trial.- Selection of Patients.- Procedure.- Assessment of Prior Dietary Status.- Monitoring Compliance and Nutrient Intake.- The Experimental and Control Diets.- Monitoring the Effects of the Diets.- Comparison of Results from the Two Diets.- Clinical Global Impressions.- Parent and Teacher Reports.- Ease of Following the Diets.- Informal Comments.- Dietary Habits and Nutrient Intake.- Follow-Up of the Children after Two Years.- Discussion and Interpretation.- 3 The Challenge Model.- The Problem of Natural Salicylates.- Challenging with Food Dyes.- A Food Challenge Case Study.- The Cookie Challenge.- 4 A Second Challenge Study.- Challenge Trial Two.- Selection of Subjects.- Design of Trial Two.- Results.- Case Studies of Double-Blind Responders.- Billie (No. 167).- Jimmie (No. 163).- Darlene (No. 057).- Criteria and Noncriteria Subjects.- Summary and Discussion of Challenge Trial Two.- 5 Foods, Food Dyes, and Allergies.- The Tension-Fatigue Syndrome.- The Cytotoxic Test.- A Third Challenge Trial.- Selection of Subjects.- Design and Procedure.- Results.- Reasons for Terminations.- Effects of Challenge and Cytotoxic Reaction.- Summary of Cytotoxic Studies.- 6 Food Dyes, Activity, and Learning.- Paired-Associate Learning.- Activity Level.- Behavioral Ratings.- Subjects.- Design and Procedure.- Results.- 7 Food Additives and Behavior: The Evidence.- The Wisconsin Studies.- The Williams Study.- The FDA Contract Study.- The University of Toronto Studies.- Summary and Conclusions.- Appendix 1 Children's Psychiatric Rating Scale.- Appendix 2 Study Procedures And Informed Consent For Diet Versus Control Comparison.- Appendix 3 Hyperkinesis Study Diet.- Appendix 4 The Cytotoxic Food Test.- Appendix 5 Observational Rating Scales.- References.