Computational Biology - Ralf Blossey

Computational Biology

A Statistical Mechanics Perspective

(Autor)

Buch | Hardcover
276 Seiten
2006
Chapman & Hall/CRC (Verlag)
978-1-58488-556-6 (ISBN)
108,45 inkl. MwSt
zur Neuauflage
  • Titel erscheint in neuer Auflage
  • Artikel merken
Zu diesem Artikel existiert eine Nachauflage
Focuses on the interface between statistical physics and bioinformatics. Introducing both equilibrium and nonequilibrium statistical mechanics, this work applies these methods to understand and model the properties of various biomolecules and biological networks at the systems level.
Quantitative methods have a particular knack for improving any field they touch. For biology, computational techniques have led to enormous strides in our understanding of biological systems, but there is still vast territory to cover. Statistical physics especially holds great potential for elucidating the structural-functional relationships in biomolecules, as well as their static and dynamic properties.

Breaking New Ground
Computational Biology: A Statistical Mechanics Perspective is the first book dedicated to the interface between statistical physics and bioinformatics. Introducing both equilibrium and nonequilibrium statistical mechanics in a manner tailored to computational biologists, the author applies these methods to understand and model the properties of various biomolecules and biological networks at the systems level.

Unique Vision, Novel Approach
Blossey combines his enthusiasm for uniting the fields of physics and computational biology with his considerable experience, knowledge, and gift for teaching. He uses numerous examples and tasks to illustrate and test understanding of the concepts, and he supplies a detailed keyword list for easy navigation and comprehension. His approach takes full advantage of the latest tools in statistical physics and computer science to build a strong set of tools for confronting new challenges in computational biology.

Making the concepts crystal clear without sacrificing mathematical rigor, Computational Biology: A Statistical Mechanics Perspective is the perfect tool to broaden your skills in computational biology.

STATISTICAL MECHANICS
Equilibrium Statistical Mechanics
Z: The Partition Function
Relation to Thermodynamics
Computing Z
Nonequilibrium Statistical Mechanics
Stochastic Processes
The Master Equation
Fluctuation Theorems
The Fokker-Planck and Langevin Equations
Sequence Alignment: A Nonequilibrium Phase Transition
BIOMOLECULES
Molecules, Code and Representation
DNA and RNA: The Building Blocks
Representing RNA Structure
Proteins
DNA
Thermal Stability of DNA: The Melting Transition
The Melting Profiles of Genomic DNA and cDNA
Hybridizing DNA
RNA
Computing RNA Secondary Structure: Combinatorics
The RNA Partition Function
RNA Phase Behavior and Folding Kinetics
Proteins
Proteins: Folding
Proteins: Docking
Electrostatics
Chromatin
Bacterial Chemotaxis: Cooperativity Once More
NETWORKS
Network Dynamics I: Deterministic
Deterministic Dynamics: ?-Repressor Expression
The Turing Insight
The Min System
Network Dynamics II: Fluctuations
Noise in Signaling
Stochastic Cascades
Stochastic Focusing
Fluctuating Gene Network Dynamics
Extrinsic vs. Intrinsic Noise
Networks: Structure
Networks as Graphs
Probability Generating Functions and Network Characteristics
Statistical Mechanics of Networks
Network Growth
INDEX

Erscheint lt. Verlag 25.5.2006
Reihe/Serie Chapman & Hall/CRC Mathematical and Computational Biology
Zusatzinfo 500 equations; 4 Tables, black and white; 8 Illustrations, color; 60 Illustrations, black and white
Sprache englisch
Maße 156 x 235 mm
Gewicht 534 g
Themenwelt Mathematik / Informatik Informatik Theorie / Studium
Naturwissenschaften Biologie
ISBN-10 1-58488-556-4 / 1584885564
ISBN-13 978-1-58488-556-6 / 9781584885566
Zustand Neuware
Haben Sie eine Frage zum Produkt?
Mehr entdecken
aus dem Bereich
was jeder über Informatik wissen sollte

von Timm Eichstädt; Stefan Spieker

Buch | Softcover (2024)
Springer Vieweg (Verlag)
37,99
Grundlagen – Anwendungen – Perspektiven

von Matthias Homeister

Buch | Softcover (2022)
Springer Vieweg (Verlag)
34,99
Eine Einführung in die Systemtheorie

von Margot Berghaus

Buch | Softcover (2022)
UTB (Verlag)
25,00