Teratogens (eBook)

Front Cover 1
TERATOGENS: Chemicals Which Cause Birth Defects 4
Copyright Page 5
Table of Contents 10
INTRODUCTION 14
CHAPTER 1 HOW TO OBTAIN INFORMATION ABOUT THE TERATOGENIC POTENTIAL OF CHEMICALS 19
1. Introduction 19
2. Data Bases Specializing in Teratology 20
3. Secondary Literature Sources Containing Toxicological Information 34
4. Reference Books 46
5. Teratology Information Services 47
6. Conclusion 49
CHAPTER 2 REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES AS A SOURCE FOR COMPILING A LIST OF TERATOGENS 55
Appendix I 61
Appendix II (These Appendices contain a list of 4,974 chemicals from RTECs which cause reproductive effects.) 236
CHAPTER 3 REPRODUCTIVE HAZARDS IN INDUSTRY: IDENTIFICATION AND PREVENTION 252
1. Introduction 252
2. Mechanisms of Reproductive Toxicity 252
3. Evidence on Occupational Hazards 253
4. Prevalent Exposures 254
5. Clues from Experimental Data 256
Conclusions 258
CHAPTER 4 TERATOGENIC CHEMICALS IN UNDERGRADUATE GENERAL CHEMISTRY LABORATORIES 260
Potential Teratogens in General Chemistry Laboratory Manuals 261
1. Potentially Teratogenic Metals 263
2. Potentially Teratogenic Inorganic Compounds 264
3. Potentially Teratogenic Organic Compounds 264
4. Potentially Teratogenic Gases 266
Conclusions 267
CHAPTER 5 SAFE HANDLING OF TERATOGENIC CHEMICALS 269
1. Handling Teratogens in the Laboratory 269
2. Handling Teratogens in Industrial Operations 271
3. Handling Teratogens in the Community 272
CHAPTER 6 USE OF REGISTERED DATA IN STUDIES OF OCCUPATIONAL EXPOSURE AND PREGNANCY OUTCOME 273
1. Introduction 273
2. Study Strategy 273
3. Registers on Pregnancy Outcome 275
4. Registers on Occupational Groups 277
5. Examples 278
6. Conclusions 282
CHAPTER 7 LONG-TERM EFFECTS OF CHEMICALS ON DEVELOPING BRAIN AND BEHAVIOR 284
1. Chemical Hazards for Developing Brain and Behavior 284
2. Passage of Potentially Noxious Substances into the Fetus and Infant 290
3. Derangements of Brain Development 292
4. Effects on Behavioral State Development 297
5. Experimental Effects of Chemicals on Behavioral Development 300
6. Methodological Aspects of Neurobehavioral Teratology 309
CHAPTER 8 TERATOGENICITY OF PESTICIDES AND OTHER ENVIRONEMTAL POLLUTANTS 328
1. Introduction 328
2. The Organohalogen Aromatic and Cyclic Pesticides and Related Compounds 332
3. The Haloalkanes and Related Pesticides 378
4. Miscellaneous Halogenated and Other Alkanes and Alkenes of Industrial Importance 379
5. Miscellaneous Insecticides: Fumigants 389
6. Organophosphorous Pesticides and Related Compounds 395
7. Carbamate Pesticides and Related Compounds 403
8. Miscellaneous Pesticides 415
9. Summary 418
SUBJECT INDEX 478