Alzheimer's Disease (eBook)

Alzheimer's Disease: Lifecourse Perspectives on Risk Reduction summarizes the growing body of knowledge on the distribution and causes of Alzheimer's disease (AD) in human populations, providing the reader with knowledge on how we define the disease and what its risk and protective factors are in the context of a life-course approach. At the conclusion of the book, the reader will understand why Alzheimer's disease likely begins at conception, then progresses through early-life and adult risk factors that ultimately impact the balance between pathologic insults in the brain and the ability of the brain to modify disease symptoms. In contrast to edited volumes that may have little cohesion, this book focuses on an integrated life-course approach to the epidemiology of dementia, in particular, Alzheimer's disease. - Reviews the current science surrounding Alzheimer's disease - Provides a primer of foundational knowledge on the disease's epidemiology and biostatistics - Utilizes a life-course approach, providing a novel and integrated view of the evolution of this illness from genes to brain reserve - Uses the 'threshold model'-a theory first described by Dr. Mortimer and widely accepted today-which incorporates the idea of risk factors for the pathology and expression of the disease - Proposes that improving brain health through modifiable behaviors can delay disease onset until a later age - Examines the future of prevention of Alzheimer's disease, a subject of great current interest

Dr. Amy R. Borenstein has been studying Alzheimer's disease for over 30 years, beginning with one of the early case-control studies of this disease. Since 1988, she has been funded by the National Institute on Aging as well as private sources to carry out a wide range of research in different countries and ethnicities focusing on Alzheimer's disease and related dementias. She led a cohort study of 2,000 Japanese Americans living in in King County, Washington (The Kame Project) for 10 years. During the past 15 years, her work has focused on early detection and prevention of Alzheimer's disease. Dr. Borenstein has published extensively in the medical literature and is recognized as a leading epidemiologist in the study of Alzheimer's disease.

---

Alzheimer's Disease: Lifecourse Perspectives on Risk Reduction summarizes the growing body of knowledge on the distribution and causes of Alzheimer's disease (AD) in human populations, providing the reader with knowledge on how we define the disease and what its risk and protective factors are in the context of a life-course approach. At the conclusion of the book, the reader will understand why Alzheimer's disease likely begins at conception, then progresses through early-life and adult risk factors that ultimately impact the balance between pathologic insults in the brain and the ability of the brain to modify disease symptoms. In contrast to edited volumes that may have little cohesion, this book focuses on an integrated life-course approach to the epidemiology of dementia, in particular, Alzheimer's disease. - Reviews the current science surrounding Alzheimer's disease- Provides a primer of foundational knowledge on the disease's epidemiology and biostatistics- Utilizes a life-course approach, providing a novel and integrated view of the evolution of this illness from genes to brain reserve- Uses the 'threshold model' a theory first described by Dr. Mortimer and widely accepted today which incorporates the idea of risk factors for the pathology and expression of the disease- Proposes that improving brain health through modifiable behaviors can delay disease onset until a later age- Examines the future of prevention of Alzheimer's disease, a subject of great current interest