International Review of Cytology (eBook)

Cover 1
Contents 6
Contributors 8
Chapter 1. Genetic Control of Germline Sexual Dimorphism in Drosophila 10
I. Introduction 10
II. Natural History of the Drosophila Germline 17
III. Primary Sex Determination Signals Revealed in Mosaics 27
IV. Germline Sexual Identity in Sex-Transformed Flies 35
V. Germline Autonomous Ovarian Tumor Loci 44
VI. Outstanding Issues 53
VII. Concluding Remarks 58
References 58
Chapter 2. Gene Silencing 70
I. Introduction 70
II. Transcriptional Gene Silencing 74
III. Posttranscriptional Gene Silencing 94
IV. Concluding Remarks 112
References 113
Chapter 3. Functional Diversity of Axonemal Dyneins as Studied in Chlamydomonas Mutants 124
I. Introduction 124
II. Brief History of Axonemal Motility Research 125
III. General Properties of Dynein 127
IV. Diversity of Axonemal Dyneins Revealed by Chlamydomonas Mutants 132
V. Functional Diversity in Dynein as Observed in Chlamydomonas Mutants 140
VI. Regulation of Dynein Activity by Central Pair/Radial Spokes 148
VII. Conclusions and Perspectives 154
References 156
Chapter 4. Genetic Alterations in Ovarian Cancer Cells That Might Account for Sensitivity to Chemotherapy in Patients 166
I. Introduction 166
II. The p53 Gene Family 168
III. Mismatch Repair Genes 182
IV. Cancer Genes 183
V. Multidrug Resistance Genes 191
VI. Concluding Remarks 192
References 193
Chapter 5. Conventional and Nonconventional Roles of the Nucleolus 208
I. Introduction 209
II. Nucleolar Structure and Assembly 211
III. The Ribosome Assembly Process 219
IV. Nucleolar Proteins 239
V. Nonconventional Roles of the Nucleolus 249
VI. Concluding Remarks 258
References 260
Index 276