International Review of Cytology (eBook)

Cover 1
Copyright Page 5
Contents 6
Contributors 8
Chapter 1. Thymic Nurse Cells: A Microenvironment for Thymocyte Development and Selection 10
I. Introduction 11
II. Characteristics of Thymic Nurse Cells (TNCs) 12
III. Proteins Involved in Thymocyte Binding to TNCs 21
IV. Roles of TNCs 25
V. Concluding Remarks 38
References 39
Chapter 2. Endoplasmic Reticulum-Associated Protein Degradation 48
I. Introduction 48
II. Substrate Recognition in the Endoplasmic Reticulum 56
III. Protein Dislocation through the Sec61 Pore 59
IV. Components of the Ubiquitin–Proteasome System Involved in ERAD 66
V. Regulation of ER-Associated Protein Degradation 76
VI. Concluding Remarks 80
References 81
Chapter 3. Functional Complexity of Intermediate Filament Cytoskeletons: From Structure to Assembly to Gene Ablation 92
I. Introduction 93
II. Intermediate Filament Protein–Gene Family 95
III. Evolution and Intermediate Filaments: Lamins„Networkers at the Inner Nuclear Membrane 99
IV. Atomic Structure and Assembly 101
V. Lessons from Transgenic Animal Studies and Human Disorders 129
VI. Caenorhabditis elegans as a Model System to Analyze IF Function 159
VII. Concluding Remarks and Perspectives 160
References 162
Chapter 4. Morphodynamics of the Follicular–Luteal Complex during Early Ovarian Development and Reproductive Life 186
I. Introduction 187
II. The Developing Ovary and the Onset of Folliculogenesis 190
III. Folliculogenesis in the Adult Ovary 210
IV. The Resting Follicle 211
V. The Growing Follicle 215
VI. The Preovulatory Follicle and Ovulation 240
VII. The Corpus Luteum 257
VIII. The Atretic Follicle 264
IX. Concluding Remarks 271
References 274
Index 298