The Genetics of Male Infertility (eBook)
XVI, 337 Seiten
Humana Press (Verlag)
978-1-59745-176-5 (ISBN)
In this book, twenty-one researchers and clinicians review the study of the genetics of male infertility, the tools available in the laboratory and clinic, the current state of knowledge, and the future of research and translation into clinical diagnostics and treatments.
New tools discussed are discussed. This book therefore serves as a guide to evidence-based clinical applications, and a preview of future possibilities.
Infertility is a common and severe health problem affecting roughly 7% of the male population. It is likely that the majority of those patients have genetic abnormalities that are the cause of their infertility. In The Genetics of Male Infertility, twenty-one researchers and clinicians review the study of the genetics of male infertility, the tools available in the laboratory and clinic, the current state of knowledge, and the future of research and translation into clinical diagnostics and treatments.This volume gives special attention to the significant technological advances in the treatment of male infertility, including intracytoplasmic injection (ICSI) in conjunction with in vitro fertilization (IVF). In addition, new tools discussed include in vitro methodologies, in silico technologies, and new model organisms.Providing a review of our current understanding of genetic causes of male infertility, The Genetics of Male Infertility serves as a guide to evidence-based clinical applications, and a preview of future possibilities.
PREFACE 5
CONTENTS 7
CONTRIBUTORS 10
I METHODS AND TOOLS FOR THE STUDY OF THE GENETICS OF MALE INFERTILITY 15
MALE INFERTILITY 15
The Genetics of Male Infertility in the Era of Genomics 16
The Use of cDNA Libraries to Demonstrate a Linkage Between Transcription and Translation in Male Germ Cells 41
Considerations When Using Array Technologies for Male Factor Assessment 48
Microarray Analysis of a Large Number of Single- Nucleotide Polymorphisms in Individual Human Spermatozoa 66
Physiological and Proteomic Approaches to Understanding Human Sperm Function 88
Genetics of Idiopathic Male Infertility 109
MEIOSIS 122
II MEIOSIS AND ERRORS OF MEIOSIS 122
The Immunocytogenetics of Human Male Meiosis 123
The Clinical Relevance of Sperm Aneuploidy 137
DNA Repair Genes and Genomic Instability in Severe Male Factor Infertility 153
III THE Y CHROMOSOME, DEVELOPMENT, T SPERMATOGENESIS, AND SPERM MATURATION M 172
Germ Cell-Specific Genes and Posttranscriptional Regulation in the Testis 173
The Genetics of Cryptorchidism 191
The Chromatoid Body and microRNA Pathways in Male Germ Cells 205
Sperm Maturation in the Epididymis 216
IV CLINICAL APPLICATIONS OF THE A STUDY OF THE GENETICS OF MALE M INFERTILITY 237
The Structure of the Y Chromosome and Its Role in Male Infertility 238
Y Chromosome Microdeletions and Haplotypes 244
The Genetics of Male Infertility 255
The Future of the Diagnosis of Male ( In) Fertility 271
Polymorphisms and Male Infertility 278
The Genetics of Abnormal Protamine Expression 293
Chromatin Damage and Male Infertility 304
Clinical Evaluation of the Genetics of Male Infertility 317
Index 329
Erscheint lt. Verlag | 8.11.2007 |
---|---|
Zusatzinfo | XVI, 337 p. 47 illus. |
Verlagsort | Totowa |
Sprache | englisch |
Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Urologie |
Studium ► 1. Studienabschnitt (Vorklinik) ► Histologie / Embryologie | |
Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik | |
Schlagworte | Chromosom • DNA • Genetic abnormalities • Genetics • Infertility • In silico technologies • Intracytoplasmic injection • In vitro fertilization • single nucleotide polymorphism • SNP • termination • transcription • Translation |
ISBN-10 | 1-59745-176-2 / 1597451762 |
ISBN-13 | 978-1-59745-176-5 / 9781597451765 |
Haben Sie eine Frage zum Produkt? |
![PDF](/img/icon_pdf_big.jpg)
Größe: 6,7 MB
DRM: Digitales Wasserzeichen
Dieses eBook enthält ein digitales Wasserzeichen und ist damit für Sie personalisiert. Bei einer missbräuchlichen Weitergabe des eBooks an Dritte ist eine Rückverfolgung an die Quelle möglich.
Dateiformat: PDF (Portable Document Format)
Mit einem festen Seitenlayout eignet sich die PDF besonders für Fachbücher mit Spalten, Tabellen und Abbildungen. Eine PDF kann auf fast allen Geräten angezeigt werden, ist aber für kleine Displays (Smartphone, eReader) nur eingeschränkt geeignet.
Systemvoraussetzungen:
PC/Mac: Mit einem PC oder Mac können Sie dieses eBook lesen. Sie benötigen dafür einen PDF-Viewer - z.B. den Adobe Reader oder Adobe Digital Editions.
eReader: Dieses eBook kann mit (fast) allen eBook-Readern gelesen werden. Mit dem amazon-Kindle ist es aber nicht kompatibel.
Smartphone/Tablet: Egal ob Apple oder Android, dieses eBook können Sie lesen. Sie benötigen dafür einen PDF-Viewer - z.B. die kostenlose Adobe Digital Editions-App.
Zusätzliches Feature: Online Lesen
Dieses eBook können Sie zusätzlich zum Download auch online im Webbrowser lesen.
Buying eBooks from abroad
For tax law reasons we can sell eBooks just within Germany and Switzerland. Regrettably we cannot fulfill eBook-orders from other countries.
aus dem Bereich