The Genetics of Male Infertility (eBook)

PREFACE 5
CONTENTS 7
CONTRIBUTORS 10
I METHODS AND TOOLS FOR THE STUDY OF THE GENETICS OF MALE INFERTILITY 15
MALE INFERTILITY 15
The Genetics of Male Infertility in the Era of Genomics 16
The Use of cDNA Libraries to Demonstrate a Linkage Between Transcription and Translation in Male Germ Cells 41
Considerations When Using Array Technologies for Male Factor Assessment 48
Microarray Analysis of a Large Number of Single- Nucleotide Polymorphisms in Individual Human Spermatozoa 66
Physiological and Proteomic Approaches to Understanding Human Sperm Function 88
Genetics of Idiopathic Male Infertility 109
MEIOSIS 122
II MEIOSIS AND ERRORS OF MEIOSIS 122
The Immunocytogenetics of Human Male Meiosis 123
The Clinical Relevance of Sperm Aneuploidy 137
DNA Repair Genes and Genomic Instability in Severe Male Factor Infertility 153
III THE Y CHROMOSOME, DEVELOPMENT, T SPERMATOGENESIS, AND SPERM MATURATION M 172
Germ Cell-Specific Genes and Posttranscriptional Regulation in the Testis 173
The Genetics of Cryptorchidism 191
The Chromatoid Body and microRNA Pathways in Male Germ Cells 205
Sperm Maturation in the Epididymis 216
IV CLINICAL APPLICATIONS OF THE A STUDY OF THE GENETICS OF MALE M INFERTILITY 237
The Structure of the Y Chromosome and Its Role in Male Infertility 238
Y Chromosome Microdeletions and Haplotypes 244
The Genetics of Male Infertility 255
The Future of the Diagnosis of Male ( In) Fertility 271
Polymorphisms and Male Infertility 278
The Genetics of Abnormal Protamine Expression 293
Chromatin Damage and Male Infertility 304
Clinical Evaluation of the Genetics of Male Infertility 317
Index 329