From Breakthrough to Blockbuster

Donald Drakeman, PhD, was the founding CEO of the US biotech company that pioneered the development of the checkpoint inhibitor cancer treatments recognized in the Nobel Prize for Medicine 2018. These products, YERVOY and OPDIVO, are being used to treat many different forms of cancer. He is a Fellow in Operations and Technology Management at the Cambridge Judge Business School, Distinguished Research Professor in the Program on Constitutional Studies at the University of Notre Dame, and a Venture Partner at Advent Life Sciences. His publications have been cited in numerous patents and by the Supreme Court of the United States. He is a Fellow of the Royal Society of Biology. A graduate of Columbia Law School, he received a PhD from Princeton University. Lisa Drakeman, PhD, was the founding CEO of one of Europe's most successful biotechnology companies. Under her leadership, the company set numerous financing records, including a record setting IPO, and inaugurated research programs leading to the new FDA-approved medicines DARZALEX (multiple myeloma) and KESIMPTA (multiple sclerosis). She is a member of the board of the Medical University of South Carolina Foundation for Research Development. She has received numerous industry honors, including the Sol J. Barer Award for Vision, Innovation, and Leadership. She has been a faculty member at Princeton University and regularly lectures on entrepreneurship at universities in the US and Europe. She received a PhD from Princeton University. Nektarios Oraiopoulos, PhD, is the Director of the MPhil Programme in Strategy, Marketing, & Operations and an Associate Professor of Operations and Technology Management at the Cambridge Judge Business School of the University of Cambridge. His research on innovation and R&D management has appeared in the leading journals of the field. He has won multiple awards and has been invited to make presentations at both academic and industry conferences. In addition to his academic work, he has advised entrepreneurial start-ups and has worked closely on research projects with numerous executives from the biopharmaceutical industry. He holds a Diploma in Electrical and Computer Engineering from the National Technical University of Athens and a PhD in Business Administration from the Georgia Institute of Technology.

List of Figures and Tables
Preface
Chapter 1: Following the Map of the Genome
Chapter 2: The Molecules
Chapter 3: The Costly Drug Development Process
Chapter 4: The Companies
Chapter 5: Biotech-Pharma Alliances
Chapter 6: The Biotech Entrepreneur
Chapter 7: The Biotech Industry Track Record
Chapter 8: The Future of the Biotech Industry
Appendix 1
Appendix 2
Bibliography
Index
About the Authors