Advances in Inorganic Chemistry (eBook)

Cover 1
Copyright Page 5
Contents 6
Chapter 1. Inorganic and Bioinorganic Reaction Mechanisms: Application of High-Pressure Techniques 10
I. Introduction 10
II. Ligand Substitution Reactions 12
III. Reactions with Small Molecules 32
IV. Electron-Transfer Reactions 44
V. Miscellaneous Reactions 56
VI. Concluding Remarks/Future Perspectives 60
References 62
Chapter 2. Substitution Studies of Second- and Third-Row Transition Metal Oxo Complexes 68
I. Introduction 69
II. Characterization of [Mo(L)(Cn)4]m- Complexes 70
III. Proton Exchange Kinetics 92
IV. Oxygen Exchange Kinetics 100
V. Cyanide Exchange Kinetics 109
VI. Comparison of the Rates of Inversion, Oxygen, and Cyanide Exchange 118
VII. In Vitro and In Vivo Reactivity of Technetium and Rhenium Complexes 124
References 131
Chapter 3. Protonation, Oligomerization, and Condensation Reactions of Vanadate(V), Molybdate(VI), and Tungstate(VI) 136
I. Introduction 136
II. Vanadate(V) 137
III. Molybdate(VI) 92
IV. Tungstate(VI) 169
V. Mixed Polyoxoanions 181
VI. Concluding Remarks 185
References 186
Chapter 4. Medicinal Inorganic Chemistry 192
I. Introduction 193
II. Anticancer Agents 195
III. Photodynamic and Sonodynamic Therapy 232
IV. Radiopharmaceuticals 235
V. Magnetic Resonance Imaging Contrast Agents 244
VI. Anti-infective Agents 249
VII. Anti-inflammatory and Antiarthritic Agents 262
VIII. Bismuth Antiulcer Drugs 268
IX. Neurological Agents 270
X. Cardiovascular and Hematopoietic System 274
XI. Insulin Mimetics 276
XII. Chelation Therapy 279
XIII. Metal Activation of Organic Drugs 282
XIV. Metalloenzyme Inhibitors as Drugs 286
XV. Conclusion and Outlook 291
References 292
Chapter 5. The Cobalt(III)-Promoted Synthesis of Small Peptides 316
I. Introduction 316
II. Genealogy 317
III. Synthetic Approaches 322
IV. Cobalt(III) as a Protecting Group 339
V. Optical Purity and Epimerization 342
VI. Mechanisms of Ester Aminolysis 356
VII. Peptide Synthesis at Metal Centers Other Than Cobalt(III) 370
VIII. Experimental Methods 375
IX. Concluding Remarks 378
References 380
Chapter 6. Structures and Reactivities of Platinum-Blues and the Related Amidate-Bridged PlatinumIII Compounds 384
I. Introduction 385
II. Syntheses and Structures of Platinum-Blues and Related Amidate-Bridged PlatinumIII Compounds 385
III. Basic Spectroscopic Properties of Platinum-Blues and Related Platinum (3.0+) Complexes 397
IV. Basic Reactions in Solution 407
V. Catalysis of Amidate-Bridged Platinum(III) Complexes 416
VI. Organometallic Chemistry of Dinuclear Pt(III) Complexes 418
VII. Antitumor Active Platinum-Blue Complexes 430
References 432
Index 438
Contents of Previous Volumes 450