Cartilage: From Biology to Biofabrication

  Prof. Mohamadreza Baghaban Eslaminejad is the Head of Bone and Cartilage group at Royan Institute for Stem Cell Biology and Technology, Tehran, Iran. He founded the adult stem cell lab in 2004 and started his research on mesenchymal stem cells as a potent tool in cell therapy for orthopedic diseases. He has supervised numerous investigations in basic sciences, preclinical and some clinical trials related to regenerative medicine. He has been appreciated with over 6 major national and international awards notably, Royan International Research Award for Reproductive Biomedicine and Stem Cell Researches (2006), the award for the Leading Researcher of Tehran (2007), The Best Researcher Award from Razi Medicine Festival (2009), the award from National Festival for Commemorating Distinguished Researchers (2010), the award for the exemplary scientist and staff of the year 2015 by ACECR (The Academic Center for Education, Culture and Research, Iran). In 2018 and2019, he was included in the list of scientific leaders of Iran. Springer Nature selected one of the Eslaminejad chapter books with the title of “3D Printing in Dentistry” as one of 2020 highlighted research. He has published more than 230 articles and 180 abstracts in peer-reviewed journals as well as national and international conferences. He has also contributed to 20 chapters and authored three books.  Dr Samaneh Hosseini is an Assistant Professor at Cell Engineering Department at Royan Institute, Tehran, Iran. Her research interest is in Tissue Engineering with specialization on biomineralization, mimetic peptides, cell-based tissue engineering for regeneration of bone and cartilage tissues. She has conducted several research projects in both basic sciences and preclinical studies in the fields of tissue engineering and regenerative medicine. She has served as a referee for a number of international journals including, Stem Cell Research and Therapy (UK), International Journal of Biological Macromolecules (Netherlands), Journal of Cellular physiology (USA), Cell Proliferation (UK) and Cell Journal (Iran). She has more than 10 years of teaching experience in tissue engineering and nanobiotechnology. She has also published more than 30 research articles in the peer-reviewed international journal and served as an author or co-author in several book chapters. One of her publication, “3D printing in Dentistry” was one of the Springer Nature 2020 highlights.

Chapter 1. Introduction to Cartilage Tissue; Development, Structure and Functions.- Chapter 2. Cartilage defects and diseases: conventional therapies and its limitations.- Chapter 3. Strategies to Control Mesenchymal Stem Cell Differentiation for Regenerating Phenotypically Defined Articular Cartilage.- Chapter 4. Single Cell Analysis Approaches in Diagnostic and Therapeutic.- Chapter 5. The Importance of Mechanical Stimulation in Cartilage Formation: Applications of Bioreactors.- Chapter 6. Signaling Pathways Regulating Cartilage Formation.- Chapter 7. Role and Application of Biomolecules for Regeneration of Cartilage Tissue.- Chapter 8. Extracellular Matrix Miomimicry for Cartilage Tissue Formation.- Chapter 9. Cartilage Tissue Engineering; Advances and Frontiers.- Chapter 10. Advances in Hydrogels for Cartilage Regeneration.- Chapter 11. Shape Memory Polymers in Cartilage Tissue Engineering.- Chapter 12. Widely-used Biomaterials in Cartilage Biofabrication.- Chapter 13. Importance of 3D Printing Techniques in Cartilage Tissue Engineering.- Chapter 14. Cell Therapy as a Novel Therapeutic Approach for Cartilage Diseases.- Chapter 15. Extracellular Vesicles: A Potent Therapeutic Tool for Cartilage Regeneration.- Chapter 16. Osteochondral unit Approach for Articular Cartilage Regeneration.- Chapter 17. Stem Cells Therapy for Cartilage Regeneration in Clinic; Challenges and Opportunities.- Chapter 18. Validation of Tissue-Engineered Constructs: Preclinical and Clinical Studies.