Pharmacotherapeutic Botanicals for Cancer Chemoprevention (eBook)

The book presents a comprehensive and up-to-date overview of phytochemicals as efficient cancer therapeutics. Over the last few decades there has been a paradigm shift from conventional cancer therapeutic approaches to alternative and complementary medicinal approaches especially using phytoconstituents from natural products. As such, the book provides an in-depth understanding of phytochemicals targeting diverse signaling pathways involved in cancer along with the evaluation of the cancer modulatory effects of phytochemicals. It also highlights the potential modulatory effect of single nucleotide polymorphisms (SNPs) on the cancer-associated cellular pathways and their interactions with the phytochemicals. Further, it analyzes the drug delivery methods, bioavailability of active components of botanicals, and toxicity of phytochemicals. Lastly, the book elucidates the 3D cell culture and animal models systems to analyze the beneficial effects of phytochemicals in cancer.

Dr. Manish Kumar is an Assistant Professor of Botany at S.D. College, Barnala, Punjab, India. He holds M.Sc. (Hons.), M.Phil. & Ph.D. in Botany from Guru Nanak Dev University, Punjab, India. He has over 3 years of teaching and 9 years of research experience in cancer chemoprevention, cancer cell therapeutics, environmental mutagenesis, and medicinal plants. He has published more than 35 research articles in journals and books of international repute with a cumulative impact factor of more than 35. He is an editorial board member of various national and international journals.

Dr. Ashita Sharma is currently working as an Associate Professor of Environmental Sciences at Chandigarh University, Gharuan, Mohali, India. She has completed her M.Sc. (Hons.) and Ph.D. in Environmental Sciences from Guru Nanak Dev University, Amritsar, India. Dr. Sharma has over 6 years of teaching experience and 7 years of research experience in soil remediation, environmental genotoxicity/carcinogenicity, and biomonitoring. During her research, she has published numerous articles in reputed international journals and books. She is a member of various professional societies.

Dr. Praveen Kumar is currently working as a Postdoctoral Researcher at the Technion, Israel Institute of Technology Haifa, Israel. He has completed his Ph.D. from the National Institute of Immunology, New Delhi, India. He has over 9 years of research experience in molecular cell biology and cancer metabolism. His specializations include cancer cell metabolomics, cell cycle metabolomics, and metabolomics based drug screening.

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The book presents a comprehensive and up-to-date overview of phytochemicals as efficient cancer therapeutics. Over the last few decades there has been a paradigm shift from conventional cancer therapeutic approaches to alternative and complementary medicinal approaches especially using phytoconstituents from natural products. As such, the book provides an in-depth understanding of phytochemicals targeting diverse signaling pathways involved in cancer along with the evaluation of the cancer modulatory effects of phytochemicals. It also highlights the potential modulatory effect of single nucleotide polymorphisms (SNPs) on the cancer-associated cellular pathways and their interactions with the phytochemicals. Further, it analyzes the drug delivery methods, bioavailability of active components of botanicals, and toxicity of phytochemicals. Lastly, the book elucidates the 3D cell culture and animal models systems to analyze the beneficial effects of phytochemicals in cancer.