Xenotransplantation

Introduction: The Present Status of Xenotransplantation Research.- Tools for Molecular Studies in Xenotransplantation.- Proteomic Protocols for Differential Protein Expression Analyses.- Specific Detection of Neu5Gc in Animal Tissues by Immunohistochemistry.- Xenoantibodies and Complement Activity Determinations by Flow Cytometry in Pig-to-Primate Xenotrasplantation.- 3D Cell-Culture Models for the Assessment of Anticoagulant and Anti-inflammatory Properties of Endothelial Cells.- Cell-based Assays for Modeling Xenogeneic Immune Responses.- Determination of Redox Status in Serum.- Generation of Genetically Modified Mice using CRISPR/Cas9.- Genome-wide PERV Inactivation in Pigs using CRISPR cas9.- Co-transplantation of Vascularized Thymic Graft with Kidney in Pig-to-Non-human Primates for the Induction of Tolerance Across Xenogeneic Barriers.- Xenogeneic Lung Transplantation Models.- Liver Xenotransplantation in a Non-humanPrimate Model.- Intra-bone Bone Marrow Transplantation in Pig-to-Non-human Primates for the Induction of Tolerance Across Xenogeneic Barriers.- Studying Xenograft Rejection of Bioprosthetic Heart Valves.- Corneal Xenotransplantation: Anterior Lamellar Keratoplasty.- Rat Model of Intra-articular Chondrocyte Xenotransplantation.- Porcine Hepatocytes: Isolation and Liver Tissue Engineering for Xenotransplantation.- Pig-to-Macaque Islet Xenotransplantation.- Regulation of Clinical Xenotransplantation: A Reappraisal of the Legal, Ethical and Social Aspects Involved.