Integrated Drug Discovery Technologies

Mei, Houng-Yau; Czarnik, Anthony W.

From gene to screen: target identification and validation Coupling Genotype to Phenotype; functional genomics; integrated proteomics technologies; where science meets silicone - microfabrication techniques and their scientific applications; SNP scoring for drug discovery applications; protein display chips; integrated proteomics technologies and in vitro validation of molecular tests. High throughput screening: high throughput screening as a discovery resource; fluorescence correlation spectroscopy (FCS) and FCS-related confocal fluorimetric methods (FCS + plus) multiple read-out options or miniaturized screening; homogeneous time-resolved fluorescence (HTRF); ADME-tox screening in drug discovery; screening lead compounds in the post-genomic era - an integrated approach to knowledge building from living cells.