Bugs as Drugs

Baylor College of Medicine, Molecular Virology and Microbiology, USA.

A. Traditional Probiotic Approaches


1. Biochemical Features of Beneficial Microbes: Foundations for Therapeutic Microbiology


Melinda A. Engevik and James Versalovic


2. The Genomic Basis of Lactobacilli as Health-Promoting Organisms


Elisa Salvetti and Paul W. O'Toole


3. Bifidobacteria and their Health-Promoting Effects


Claudio Hidalgo-Cantabrana et al.


B. Next-Generation Bacteriotherapy: Opportunities in Chronic Diseases


4. Microbial Interactions and Interventions in Colorectal Cancer


Terence Van Raay and Emma Allen-Vercoe


5. Microbial Impact on Host Metabolism: Opportunities for Novel Treatments of Nutritional Disorders?


Hubert Plovier and Patrice D. Cani


6. Therapeutic Opportunities in the Vaginal Microbiome


Gregor Reid


7. Lung Microbiota and Its Impact on the Mucosal Immune Phenotype


Benjamin G. Wu and Leopoldo N. Segal


8. Microbiota, Liver Diseases, and Alcohol


Anne-Marie Cassard, Philippe Gerard, and Gabriel Perlemuter


9. The Potential of Probiotics as a Therapy for Osteoporosis


Fraser L. Collins et al.


10. Ecological Therapeutic Opportunities for Oral Diseases


Anilei Hoare, Philip D. Marsh, and Patricia I. Diaz


C. Control of Infectious Disease by Microbes


11. Control of Clostridium difficile Infection by Defined Microbial Communities


James Collins and Jennifer M. Auchtung


12. Fecal Microbiota Transplantation: Therapeutic Potential for a Multitude of Diseases beyond Clostridium difficile


Guido J. Bakker and Max Nieuwdorp


13. Enterococci and their Interactions with the Intestinal Microbiome


Krista Dubin and Eric G. Pamer


D. Next-Generation Microbial Therapeutics: Tools and Regulation


14. Engineering Diagnostic and Therapeutic Gut Bacteria


Brian P. Landry and Jeffrey J. Tabor


15. Use of Traditional and Genetically Modified Probiotics in Human Health: What Does the Future Hold?


Luis G. Bermudez-Humaran and Philippe Langella


16. Genetic Tools for the Enhancement of Probiotic Properties


Laura Ortiz-Velez and Robert Britton


17. Genome Editing of Food-Grade Lactobacilli to Develop Therapeutic Probiotics


Jan-Peter van Pijkeren and Rodolphe Barrangou


18. United States Regulatory Considerations for Development of Live Biotherapeutic Products as Drugs


Sheila M. Dreher-Resnick, Scott Stibitz, and Paul E. Carlson, Jr.


E. Indirect Strategies to Target Microbiome Function for Health


19. Bacteriophage Clinical Use as Antibacterial "Drugs": Utility and Precedent


Stephen T. Abedon


20. Modulation of the Gastrointestinal Microbiome with Nondigestible Fermentable Carbohydrates to Improve Human Health


Edward C. Deehan et al.