Sample Sizes for Clinical, Laboratory and Epidemiology Studies - David MacHin

Sample Sizes for Clinical, Laboratory and Epidemiology Studies

(Autor)

Buch | Hardcover
416 Seiten
2018 | 4th Edition
Wiley-Blackwell (Verlag)
978-1-118-87494-3 (ISBN)
100,53 inkl. MwSt
An authoritative resource that offers the statistical tools and software needed to design and plan valid clinical studies
Now in its fourth and extended edition, »Sample Sizes for Clinical, Laboratory and Epidemiology Studies« includes the sample size software (SSS) and formulae and numerical tables needed to design valid clinical studies. The text covers clinical as well as laboratory and epidemiology studies and contains the information needed to ensure a study will form a valid contribution to medical research.

The authors, noted experts in the field, explain step by step and explore the wide range of considerations necessary to assist investigational teams when deriving an appropriate sample size for their when planned study. The book contains sets of sample size tables with companion explanations and clear worked out examples based on real data. In addition, the text offers bibliography and references sections that are designed to be helpful with guidance on the principles discussed.

This revised fourth edition:

  • Offers the only text available to include sample size software for use in designing and planning clinical studies
  • Presents new and extended chapters with many additional and refreshed examples
  • Includes clear explanations of the principles and methodologies involved with relevant practical examples
  • Makes clear a complex but vital topic that is designed to ensure valid methodology and publishable results
  • Contains guidance from an internationally recognised team of medical statistics experts

Written for medical researchers from all specialities and medical statisticians, »Sample Sizes for Clinical, Laboratory and Epidemiology Studies« offers an updated fourth edition of the important guide for designing and planning reliable and evidence based clinical studies.

David Machin, Leicester Cancer Research Centre, University of Leicester and Medical Statistics Group, School of Health and Related Research,University of Sheffield, UK.

Michael J. Campbell, Medical Statistics Group, School of Health and Related Research,University of Sheffield, UK

Say Beng Tan, SingHealth Duke-NUS Academic Medical Centre, Singapore.

Sze Huey Tan, Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre, Singapore.

Preface vii


1 Basic Design Considerations 1


2 Further Design Considerations 29


3 Binary Outcomes 41


4 Ordered Categorical Outcomes 55


5 Continuous Outcomes 67


6 Rate Outcomes 81


7 Survival Time Outcomes 97


8 Paired Binary, Ordered Categorical and Continuous Outcomes 115


9 Confidence Intervals 135


10 Repeated Outcome Measures 155


11 Non ]Inferiority and Equivalence 167


12 Cluster Designs 193


13 Stepped Wedge Designs 211


14 More than Two Groups Designs 225


15 Genomic Targets and Dose ]Finding 235


16 Feasibility and Pilot Studies 247


17 Therapeutic Exploratory Trials: Single Arm with Binary Outcomes 265


18 Therapeutic Exploratory Trials: Survival, Dual Endpoints, Randomised and Genomic Targets 281


19 The Correlation Coefficient 303


20 Observer Agreement Studies 315


21 Reference Intervals and Receiver Operating Curves 337


22 Sample Size Software 359


Cumulative References 361


Index

Erscheinungsdatum
Verlagsort Hoboken
Sprache englisch
Maße 187 x 235 mm
Gewicht 820 g
Einbandart gebunden
Themenwelt Medizin / Pharmazie Allgemeines / Lexika
Medizin / Pharmazie Medizinische Fachgebiete Laboratoriumsmedizin
Technik Medizintechnik
Schlagworte Klinische Forschung • Klinische Studien
ISBN-10 1-118-87494-3 / 1118874943
ISBN-13 978-1-118-87494-3 / 9781118874943
Zustand Neuware
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