Functional Molecules from Natural Sources (eBook)

Stephen K. Wrigley has worked in the field of industrial natural products drug discovery and development for twenty five years. He is currently Chief Technical Officer at Hypha Discovery Ltd., where his scientific interests are focused on the identification and evaluation of novel basidiomycete metabolites with anticancer and antimicrobial activities. Prior to joining Hypha, he led efforts to characterize and develop new lipopeptide antibiotics at RecombinoGen Ltd. Steve was formerly Senior Director of Research for Cubist Pharmaceuticals (UK) Ltd., where he led a team engaged in antibiotic screening and participated in programmes to generate improved lipopeptides through chemical and genetic modification. He had previously held research management and scientific positions involving microbial product discovery at TerraGen Discovery, Inc., Xenova Ltd. and Glaxo Group Research Ltd. Steve obtained BSc and PhD degrees, both in chemistry, from Imperial College, University of London, in 1982 and 1985, respectively.

Antitumour Agents from Nature; From Natural Products to Medicinal Chemistry; New Approaches for Drug Discovery with Natural Products; Biosynthesis and Biosynthetic Engineering of Nonribosomal Lipopeptides; Why Natural Product Discovery Won't Meet the Requirements of Market-Driven Economics; Marine Natural Products; From the Seabed to the Hospital Bed; Development of Lantibiotics for Treatment of Nosocomial Infections; Imino Sugars: A Major New Group of Therapeutic Agents; Well, Naturally; Modifying Oxidation and Glycosylation Events in the Biosynthesis of Natural Product Anticancer Drugs û Challenges for Combinatorial Biosynthesis; Pleuromutilins: Antibiotic Optimisation for Human Therapeutic Use; Acetogenic Anthraquinones and Alkaloids - Online Structural Elucidation, Biosynthesis, Bioactivities and Total Synthesis; Finding New Antibacterials: Opening a Window on the Black Box of Natural Product Discovery; Potential Plant Natural Products for Management of Neglected Diseases; Chemical Diversity by Other Means: The Biosynthesis of Polyketide Drugs; Structural, Synthetic and Biosynthetic Studies on an 'Acyl Transferase-Less. Polyketide Antibiotic, Mupirocin; Switching on Defence Genes with Plant Secondary Metabolites; Natural Products as Leads for New and Innovative Crop Protection Chemicals