Handbook for Chemical Process Research and Development

Dr. Wenyi Zhao, Senior Research Scientist (Process Chemistry), Member of the American Chemical Society. 1980–1990: Ph.D., Organic/Physical Organic Chemistry, Nanjing University, China. 1990–1992: Postdoctoral fellow at the Institute of Chemistry, Chinese Academy of Sciences, Beijing. 1992–1995: Associate Professor at the Institute of Photographic Chemistry, Chinese Academy of Sciences, Beijing (now the Institute of Chemistry, Chinese Academy of Sciences, Beijing). 1995–2001: Senior Research Associate in the Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas. Early in 2001, Dr. Zhao moved into the private sector to become a process chemist in the pharmaceutical industry in the United States. He is the author of numerous journal articles and holds several patents.

Chapter 1: Modes Of Reagent Addition – Control of Impurity Formation



Chapter 2: Process Optimization



Chapter 3: Hazardous Reactions



Chapter 4: Catalytic Reactions



Chapter 5: Grignard Reagent And Related Reactions



Chapter 6: Challenging Reaction Intermediates



Chapter 7: Protecting Groups



Chapter 8: Reaction Solvents



Chapter 9: Base Reagent Selection



Chapter 10: Reagents For Amide Formation



Chapter 11: Various Reagent Surrogates



Chapter 12: Telescope Approach



Chapter 13: Stereochemistry



Chapter 14: Design Of New Synthetic Route



Chapter 15: Reaction Workup



Chapter 16: Pharmaceutical Salts



Chapter 17: Solid Form