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Handbook for Chemical Process Research and Development, Second Edition

(Autor)

Buch | Hardcover
866 Seiten
2023 | 2nd edition
CRC Press (Verlag)
978-1-032-25927-7 (ISBN)
218,20 inkl. MwSt
This handbook is designed to provide readers with an unprecedented strategy approach to mechanism-guided process development, helping process chemists and students in industrial chemistry develop chemical processes efficiently. The latest edition addresses common process issues such as safety, cost, robustness, and environmental impact.
This fully updated second edition reflects the significant changes in process chemistry since the first edition and includes more common process issues such as safety, cost, robustness, and environmental impact. Some areas have made notable progress such as process safety, stereochemistry, new reagents and reagent surrogates. Forty years ago there were few process research and development activities in the pharmaceutical industry, partly due to the simplicity of drug molecules. With increasing structural complexity especially the introduction of chiral centers into drug molecules and stricter regulations, process R&D has become one of the critical departments for pharmaceutical companies.

Features:

This unique volume now in its second edition is designed to provide readers with an unprecedented strategy and approach which will help chemists and graduate students develop chemical processes in an efficient manner.
Promotes an industrial mindset concerning safety and commercial viability when developing methods.
The author discusses development strategies with case studies and experimental procedures.
Focuses on mechanism-guided process development which provides readers with practical strategies and approaches.
Addresses more common process issues such as safety, cost, robustness, and environmental impact.
This book provides a new direction for scientists, researchers, and students in materials science and polymer chemistry who seek to better understand the chemistry behind conducting polymers and improve their performance for use in advanced energy applications.

Dr Wenyi Zhao, Senior Research Scientist (Process Chemistry), Member of American Chemical Society. 1980-1990: Ph.D., Organic/Physical Organic Chemistry, Nanjing University, China. 1990-1992: Postdoctoral fellow in Institute of Chemistry, Chinese Academy of Sciences, Beijing. 1992-1995: Associate professor in Institute of Photographic Chemistry, Chinese Academy of Sciences, Beijing (Now becomes Institute of Chemistry, Chinese Academy of Sciences, Beijing). 1995-2001: Sr. research associate in Department of Chemistry, Texas Tech University, Lubbock, Texas 2001 - 2005. Dr Wenyi Zhao then moved into the private sector to become a process chemist in the pharmaceutical industry in the US with over 15 years of experience. He is the author of numerous journal articles and holds several patents.

1. Reaction solvent selection

2. Reagent selection

3. Various reagent surrogates

4. Modes of reagent addition -control of impurity formation

5. Process optimization with additives

6. Process optimization of catalytic reactions

7. Process optimization of problematic reactions

8. Hazards of oxidation and reduction reactions

9. Other hazardous reactions

10. Hazardous reagents

11. Grignard reagent and related reactions

12. Challenging reaction intermediates

13. Protecting groups

14. Telescope approach

15. Design of new synthetic route

16. Stereochemistry

17. Various quenching strategies

18. Various isolation and purification strategies

19. Methods for residual metal removal

20. Methods for impurity removal

21. Pharmaceutical salts

22. Solid form

Erscheinungsdatum
Zusatzinfo 24 Tables, black and white; 2 Line drawings, color; 642 Line drawings, black and white; 2 Illustrations, color; 642 Illustrations, black and white
Verlagsort London
Sprache englisch
Maße 178 x 254 mm
Gewicht 1880 g
Themenwelt Naturwissenschaften Chemie Organische Chemie
Naturwissenschaften Chemie Technische Chemie
Technik Umwelttechnik / Biotechnologie
ISBN-10 1-032-25927-2 / 1032259272
ISBN-13 978-1-032-25927-7 / 9781032259277
Zustand Neuware
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