Biophysics and Biochemistry of Cartilage by NMR and MRI

Universität Leipzig, Germany

Part One – Introduction: Introduction to Cartilage;

Osmotic Properties of Cartilage;

Introduction to NMR and MRI;

The Magic Angle Effect in NMR and MRI of Cartilage;

Part Two – Physical Properties of Cartilage by Relaxation Anisotropy;

Experimental NMR and MRI Techniques for Cartilage Research: Physical Properties of Cartilage by Relaxation Anisotropy;

Chemical Properties of Cartilage Studied Using Charged Ions;

Quantification of Articular Cartilage Microstructure by the Analysis of the Diffusion Tensor;

Sodium and Other Exotic Methods in NMR and MRI of Cartilage;

Multi-Quantum Filtered NMR and MRI of Cartilage;

Solid-State NMR Techniques to Study the Molecular Dynamics in Cartilage;

Ultrashort Echo Time Imaging of Articular Cartilage;

Low-Field and Field-Cycling NMR and MRI of Cartilage;

The Influence of Specimen and Experimental Conditions on NMR and MRI of Cartilage;

Part Three – Biomechanical Properties of Cartilage by NMR and MRI;

Diffusion MRI and Poroelastic Biomechanics of Articular Cartilage;

Combining Multi-Modal MRI and Biomechanical Modeling to Investigate the Response of Cartilage and Chondrocytes to Mechanical Stimuli;

Loading-Induced Changes in Cartilage Studied by NMR and MRI;

Part Four– Applications and the Future of Cartilage Research by NMR and MRI;

The Critical Role of the Imaging Resolution in MRI of Cartilage – The MRI Microscope;

Multi-Component Relaxations in MRI of Cartilage;

Uni- and Multi-Parametric Magnetic Resonance Analysis of Cartilage;

Magnetic Resonance in the Assessment of Tissue Engineered Cartilage;

Complementary Imaging in MRI of Cartilage;

Quantitative MRI for Detection of Cartilage Damage;

Challenges for the Early Detection of Degenerative;

Cartilage Changes Using Magnetic Resonance Imaging In vivo in Humans;

Ultrahigh-Field Whole-Body MRI for Cartilage Imaging: Technical Challenges