Handbook of Metathesis

Robert H. Grubbs received his Ph.D. from Columbia University for work with Ron Breslow. After a postdoctoral year with Jim Collman at Stanford University, he joined the faculty at Michigan State University. In 1978, he moved to the California Institute of Technology, where he is now the Victor and Elizabeth Atkins Professor of Chemistry. Among many other awards, he received the Nobel Prize in 2005 for his research on the metathesis reaction. His research interests include polymer chemistry, organometallic catalysis, and the development of new synthetic organic methodology. Anna G. Wenzel received her PhD at Harvard University under the guidance of Prof. E. N. Jacobsen. From 2003 to 2006, she joined the group of Prof. R. H. Grubbs as an NIH Postdoctoral Scholar. In 2006, she joined the faculty as an Assistant Professor at the W. M. Keck Science Department in Claremont, California. In 2012, she was promoted to Associate Professor. Her research topics are asymmetric catalysis, organometallic chemistry, and organic synthesis. Daniel J. O?Leary received his PhD at UCLA in the group of Prof. Frank A. L. Anet. Following an NSF postdoctoral fellowship with Prof. Yoshito Kishi at Harvard University, he became Assistant Professor at Pomona College, where he is presently the Carnegie Professor of Chemistry. His research interests are in the area of organic synthesis, isotope effects, and nuclear magnetic resonance. Ezat Khosravi obtained his PhD in Polymer Science from the University of Sussex, UK in 1981. He is presently Reader in Polymer Chemistry at Chemistry Department, Durham University, UK. His research interests range from well-defined polymerization chemistry to novel polymers and biopolymers. He is internationally recognized particularly for his work on Ring Opening Metathesis Polymerization (ROMP) and related chemistry. He is the permanent secretary of the advisory board of the International Symposium on Olefin Metathesis (ISOM).

VOLUME ONE - CATALYST DEVELOPMENT AND MECHANISM
Preface
High-Oxidation State Molybdenum and Tungsten Complexes Relevant to Olefin Metathesis
Alkane Metathesis
Diastereocontrol in Olefin Metathesis: The Development of Z-Selective Ruthenium Catalysts
Ruthenium Olefin Metathesis Catalysts Supported by Cyclic Alkyl Aminocarbenes (CAACs)
Supported Catalysts and Nontraditional Reaction Media
Insights from Computational Studies on d0 Metal-Catalyzed Alkene and Alkyne Metathesis and Relation Reactions
Computational Studies of Ruthenium-Catalyzed Olefin Metathesis
Intermediates in Olefin Metathesis
Factors Affecting Initiation Rates
Degenerate Metathesis
Mechanisms of Olefin Metathesis Catalyst Decomposition and Methods of Catalyst Reactivation
Solvent and Additive Effects on Olefin Metathesis
Metathesis Product Purification
Ruthenium Indenylidene Catalysts for Alkene Metathesis

VOLUE TWO - APPLICATIONS IN ORGANIC SYNTHESIS
Preface
General Ring-Closing Metathesis
Cross-Metathesis
Vignette: Extending the Application of Metathesis in Chemical Biology - The Development of Site-Selective Peptide and Protein Modifications
Ruthenium-Catalyzed Tandem Metathesis/Non-Metathesis Processes
Enyne Metathesis
Alkyne Metathesis
Catalyst-Controlled Stereoselective Olefin Metathesis
Two Vignettes: RCM in Natural Product Total Synthesis
Metathesis of Silicon-Containing Olefins
Ring-Closing Metathesis in the Large-Scale Synthesis of Pharmaceuticals
Metathesis Strategies in Diversity-Oriented Synthesis
Olefin Metathesis: Commerical Applications and Future Opportunities
Index

VOLUME THREE - POLYMER SYNTHESIS
Preface
Synthesis of Homopolymers and Copolymers
ROMP in Dispersed Media
Telechelic Polymers
Supramolecular Polymers
Synthesis of Materials with Nanostructured Periodicity
Synthesis of Nanoparticles
Synthesis of Biodegradable Copolymers
Biologically Active Polymers
Combination of ROMP with Click Chemistry
Self-Healing Polymers
Functional Supports and Materials
Latent Ruthenium Catalysts for ROMP
ADMET Polymerization
Biorenewable Polymers
Polymerization of Substituted Acetylenes
Index