Handbook of Metathesis

Robert H. Grubbs received his Ph.D. from Columbia University for work with Ron Breslow. After a postdoctoral year with Jim Collman at Stanford University, he joined the faculty at Michigan State University. In 1978, he moved to the California Institute of Technology, where he is now the Victor and Elizabeth Atkins Professor of Chemistry. Among many other awards he received the Nobel Prize in 2005 for his research on the metathesis reaction. His research interests include polymer chemistry, organometallic catalysis, and development of new synthetic organic methodology. Ezat Khosravi obtained his PhD in Polymer Science from the University of Sussex, UK in 1981. He is presently Reader in Polymer Chemistry at Chemistry Department, Durham University, UK. His research interests range from well-defined polymerization chemistry to novel polymers and biopolymers. He is internationally recognized particularly for his work on Ring Opening Metathesis Polymerization (ROMP) and related chemistry. He is the permanent secretary of the advisory board of the International Symposium on Olefin Metathesis (ISOM).

Preface

SYNTHESIS OF HOMOPOLYMERS AND COPOLYMERS
Introduction
Initiators
Monomers
Synthesis of Polymers with Complex Architectures
Stereochemistry and Sequence Control in ROMP
Conclusion

ROMP IN DISPERSED MEDIA
Introduction
Emulsion ROMP
Dispersion ROMP
Suspension ROMP
Formation of Nanoparticles
Conclusion

TELECHELIC POLYMERS
Introduction
Mono-Telechelic Polymers
Homo-Telechelic Polymers
Hetero-Telechelic Polymers
Conclusions and Outlook

SUPRAMOLECULAR POLYMERS
Introduction
Main-Chain Supramolecular Polymers
Side-Chain-Functionalized Supramolecular Polymers
Supramolecular Architectures by Design
Conclusion

SYNTHESIS OF MATERIALS WITH NANOSTRUCTURED PERIODICITY
Introduction
Sequential ROMP
Inorganic Composite Materials
ABA Triblock Copolymers
Nanostructures with Domain Sizes Exceeding 100 nm
Conclusions

SYNTHESIS OF NANOPARTICLES
Introduction
Formation of Nanoparticles
Synthesis via Grafting-through Approach
Synthesis via Grafting-to Approach
Synthesis via Grafting-from Approach
Summary

SYNTHESIS OF BIODEGRADABLE COPOLYMERS
Introduction
Polyester-Functionalized Polymers
Peptide-Functionalized Polymers
Carbohydrate-Functionalized Polymers
Antimicrobial Polymers
Polymeric Betaines
ROMP Polymers as Drug Carriers
ROMP Polymers for Tissue Scaffolds
Conclusion

BIOLOGICALLY ACTIVE POLYMERS
Introduction
Benefits of ROMP for Bioactive Polymer Synthesis
Biologically Active Polymeric Displays
Exploiting the Bulk Properties of Polymers
Probes of Biological Processes
Outlook

COMBINATION OF ROMP WITH CLICK CHEMISTRY
Introduction
Attaching Functional Groups for Click Reaction
Copper-Catalyzed Azide/Alkyne Click Reaction
Diels-Alder Click Reaction
Thiol-Ene Reaction
Thiol-Michael Addition
Meldum's Acid-Containing Polymers as Precursor for Ketene Coupling
Nitrole Oxide Cycloaddition

SELF-HEALING POLYMERS
Introduction
Monomer Storage
Catalyst Stability and Protection
Catalyst and Monomer Choice
Intrinsic Self-Healing Polymers
Conclusions

FUNCTIONAL SUPPORTS AND MATERIALS
Introduction
Preparation of Functional Supports
Functional Monolithic Supports
Twenty-First Century Functional Supports
Summary and Outlook

LATENT RUTHENIUM CATALYSTS FOR ROMP
Introduction
Thermal Activation
Light-Induced Activation
Chemical Activation
Mechanical Acitvation
Conclusions

ADMET POLYMERIZATION
Introduction
ADMET: The Metathesis Polycondensation Reaction
ADMET of Nonconjugated Hydrocarbon Dienes
ADMET Copolymerization
ADMET of Functionalized Dienes
Functional Materials
Modeling Polyethylene
Conjugated Polymers
Solid-State Polymerization
ADMET Depolymerization
Telechelic Oligomers
Complex Polymer Architectures
Biorenewable Polymers
Conclusions and Outlook

BIORENEWABLE POLYMERS
Introduction
ADMET
ROMP
Conclusion

POLYMERIZATION OF SUBSTITUTED ACETYLENES
Introduction
Polymerization Reactions
Catalysts
Recent Catalysts for Living Polymerization
Polymerization of Monosubstituted Acetylenes
Polymerization of Disubstituted Acetylenes
Polymer Modification Reactions
Properties of Polymers

Index