Stereoselective Organocatalysis (eBook)

RAMON RIOS TORRES, PhD, is Reader in Organic Chemistry at the University of Southampton. With more than ninety peer-reviewed articles and several book chapters to his credit, Dr. Rios Torres devotes his research to the development of new asymmetric methods based on organocatalysis and organometallic chemistry as well as the application of these methods in total synthesis. Dr. Rios Torres is also the editor of The Pauson-Khand Reaction: Scope, Variations and Applications (Wiley).

PREFACE vii

CONTRIBUTORS ix

1. INTRODUCTION: A HISTORICAL POINT OF VIEW 1

Ramon Rios and Xavier Companyó

2. ACTIVATION MODES IN ASYMMETRIC ORGANOCATALYSIS
11

Albert Moyano

3. C-C BOND FORMATION BY ALDOL REACTION 81

Dorota Gryko and Dominika Walaszek

4. EXAMPLES OF METAL-FREE DIRECT CATALYTIC ASYMMETRIC
MANNICH-TYPE REACTIONS USING AMINOCATALYSIS 129

Armando Córdova

5. C-C BOND FORMATION BY MICHAEL REACTION 147

Yong Zhang and Wei Wang

6. C-C BOND FORMATION BY DIELS-ALDER AND OTHER
PERICYCLIC REACTIONS 205

Johan Franzén

7. N-HETEROCYCLIC CARBENE-CATALYZED C-C BOND FORMATION
231

Xiang-Yu Chen and Song Ye

8. a-ALKYLATION OF CARBONYL COMPOUNDS 267

Marek RemeS and Jan Vesely

9. OTHER REACTIONS FOR C-C BOND FORMATION 313

Yi-Xia Jia and Tiexin Zhang

10. CASCADE REACTIONS FORMING C-C BONDS 351

Ramon Rios, Jorge Esteban, and Xavier Companyó

11. ORGANOCATALYTIC C-N BOND FORMATION 381

Aitor Landa, Rosa López, Antonia Mielgo, Mikel Oiarbide,
and Claudio Palomo

12. C-O BOND FORMATION 433

José Alemán and Mariola Tortosa

13. CARBON-HALOGEN BOND FORMATION 465

Stacey E. Brenner-Moyer

14. C-OTHER ATOM BOND FORMATION (S, SE, B)
493

Giorgio Della Sala and Alessandra Lattanzi

15. ENANTIOSELECTIVE ORGANOCATALYTIC REDUCTIONS 529

Maurizio Benaglia, Martina Bonsignore, and Andrea Genoni

16. CASCADE REACTIONS FORMING BOTH C-C BOND AND
C-HETEROATOM BOND 559

Damien Bonne, Thierry Constantieux, Yoann Coquerel, and Jean
Rodriguez

17. ORGANOCATALYSIS IN THE SYNTHESIS OF NATURAL PRODUCTS
587

Yongcheng Ying and Xuefeng Jiang

INDEX 629

"The book is nicely structured and the chapters are
extensively supplemented by references, offering the reader a
practical overview of the field of asymmetric organocatalysis . . .
Congratulations to the editor and to all the authors for
this nice piece of work." (Angew. Chem. Int.
Ed, 1 October 2014)