In the last 3 decades, stem cells have greatly impacted the scientific and lay communities, providing huge advances in the treatment of devastating human diseases, including myocardial infarction, diabetes, muscular dystrophy, cystic fibrosis, cirrhosis, and osteoporosis. Alongside debates of induced pluripotent stem cells and embryonic stem cells has been the discovery of adult stem cells in many different tissues. While these organ resident or progenitor stem cells offer prospects to contribute to tissue regeneration, they also present challenges because of the complexity of organ structures.
This book will present the main findings to date and the important factors to be considered when considering resident stem cells in regenerative therapies. Chapters on cardiac, brain, neural, liver, kidney, skeletal muscle, bone, pancreatic, skin, and lung resident stem cells will assist in defining the level of success that has been achieved and the direction for the road ahead. With contributions from leading laboratories, open questions related to resident stem cells and regenerative therapies will also be presented for debate.
• Highlights basic research in tissue specific stem cells, experiments with animal models and clinical trials that are transforming the field of regeneration.
• Provides a clear understanding of endogenous stem cells, their role in current regenerative therapies, and prospects for future research
• Reports on the main-stream clinical approaches and in vivo experiments published in primary literature to help categorizes the advances in various aspects of regenerative therapy and illustrate opportunities for clinical applications
In the last 3 decades, stem cells have greatly impacted the scientific and lay communities, providing huge advances in the treatment of devastating human diseases, including myocardial infarction, diabetes, muscular dystrophy, cystic fibrosis, cirrhosis, and osteoporosis. Alongside debates of induced pluripotent stem cells and embryonic stem cells has been the discovery of adult stem cells in many different tissues. While these organ resident or progenitor stem cells offer prospects to contribute to tissue regeneration, they also present challenges because of the complexity of organ structures. This book will present the main findings to date and the important factors to be considered when considering resident stem cells in regenerative therapies. Chapters on cardiac, brain, neural, liver, kidney, skeletal muscle, bone, pancreatic, skin, and lung resident stem cells will assist in defining the level of success that has been achieved and the direction for the road ahead. With contributions from leading laboratories, open questions related to resident stem cells and regenerative therapies will also be presented for debate. Highlights basic research in tissue specific stem cells, experiments with animal models and clinical trials that are transforming the field of regeneration Provides a clear understanding of endogenous stem cells, their role in current regenerative therapies, and prospects for future research Reports on the main-stream clinical approaches and in vivo experiments published in primary literature to help categorizes the advances in various aspects of regenerative therapy and illustrate opportunities for clinical applications
List of Contributors
Mariana Alves Antunes Instituto de Biofísica Carlos Chagas Filho; Programa de Terapia Celular e Bioengenharia; Laboratório de Investigação Pulmonar; Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem -INBEB; Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
Alex Balduino Coordenação de Pesquisa, Universidade Veiga de Almeida (UVA), Rio de Janeiro, Brazil
Radovan Borojevic Instituto de Ciências Biomédicas Universidade Federal do Rio de Janeiro and Excellion Serviços Biomédicos SA, Petrópolis, Rio de Janeiro
Giordano Wosgrau Calloni Departamento de Biologia Celular, Embriologia e Genética, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Campus Universitário-Trindade, 88040-900, Florianópolis, Santa Catarina, Brazil
Arnold I. Caplan Skeletal Research Center, Department of Biology, Case Western Reserve University, Cleveland, Ohio, USA
Adriana B. Carvalho Instituto de Biofísica Carlos Chagas Filho; Programa de Terapia Celular e Bioengenharia; Laboratório de Cardiologia Celular e Molecular; Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem -INBEB; Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
Antonio Carlos Campos de Carvalho Instituto de Biofísica Carlos Chagas Filho; Programa de Terapia Celular e Bioengenharia; Laboratório de Cardiologia Celular e Molecular; Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem -INBEB; Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Instituto Nacional de Cardiologia, Rede de Terapia Celular, Brazil
Karen L. Christman Department of Bioengineering, University of California, San Diego, La Jolla, California, USA
Grazielle Suhett Dias Instituto de Biofísica Carlos Chagas Filho; Laboratório de Cardiologia Celular e Molecular; Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem -INBEB; Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
Milene R. Costa Instituto de Biofísica Carlos Chagas Filho; Programa de Terapia Celular e Bioengenharia; Laboratório de Físico-Química Biológica Aída Hassón-Voloch; Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem -INBEB; Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
Maria Eugenia Leite Duarte Centro de Pesquisa em Terapia Celular e Bioengenharia Ortopédica (CTCel), Instituto Nacional de Traumatologia e Ortopedia (INTO), Rio de Janeiro, Brazil Instituto de Ciências Biomédicas (ICB), Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil
Marcelo Einicker-Lamas Instituto de Biofísica Carlos Chagas Filho; Programa de Terapia Celular e Bioengenharia; Laboratório de Físico-Química Biológica Aída Hassón-Voloch; Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem -INBEB; Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
Lanuza Alaby Pinheiro Faccioli Instituto de Biofísica Carlos Chagas Filho; Laboratório de Cardiologia Celular e Molecular; Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem -INBEB; Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
Bernd K. Fleischmann Institute of Physiology I, Life and Brain Center, University of Bonn, Bonn, Germany
Regina Coeli dos Santos Goldenberg Instituto de Biofísica Carlos Chagas Filho; Programa de Terapia Celular e Bioengenharia; Laboratório de Cardiologia Celular e Molecular; Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem -INBEB; Universidade Federal doRio de Janeiro, Rio de Janeiro, RJ, Brazil
Fernanda Gubert Instituto de Biofísica Carlos Chagas Filho; Programa de Terapia Celular e Bioengenharia; Laboratório de Neurobiologia Celular e Molecular; Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem -INBEB; Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
Patrícia M. Kossugue Chemistry Institute, Biochemistry Department, Cell and Molecular Therapy Center (NUCEL), University of São Paulo, São Paulo, Brazil
Rafael S. Lindoso Instituto de Biofísica Carlos Chagas Filho; Programa de Terapia Celular e Bioengenharia; Laboratório de Físico-Química Biológica Aída Hassón-Voloch; Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem -INBEB; Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
Fernando H. Lojudice Chemistry Institute, Biochemistry Department, Cell and Molecular Therapy Center (NUCEL), University of São Paulo, São Paulo, Brazil
Rosalia Mendez-Otero Instituto de Biofísica Carlos Chagas Filho; Programa de Terapia Celular e Bioengenharia; Laboratório de Neurobiologia Celular e Molecular; Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem -INBEB; Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
Lindolfo da Silva Meirelles University of São Paulo, Ribeirão Preto, São Paulo, Brazil
Louise Mesentier-Louro Instituto de Biofísica Carlos Chagas Filho; Laboratório de Neurobiologia Celular e Molecular; Programa de Terapia Celular e Bioengenharia; Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem -INBEB; Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
Luiz Fernando Quintanilha de Mesquita Instituto de Biofísica Carlos Chagas Filho; Laboratório de Cardiologia Celular e Molecular; Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem -INBEB; Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil; Division of Laboratory, Yamaguchi University Hospital, Yamaguchi University School of Medicine, Japan; Department of Gastroenterology and Hepatology, Yamaguchi University, Graduate School of Medicine Yamaguchi University, Japan
Marcelo Marcos Morales Instituto de Biofísica Carlos Chagas Filho; Laboratório de Fisiologia Celular e Molecular; Programa de Terapia Celular e Bioengenharia; Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem -INBEB; Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
Nance Beyer Nardi Laboratory of Stem Cells and Cell Therapy, Universidade Luterana do Brazil, Canoas, Rio Grande do Sul, Brazil
M.I. Nicolescu Molecular Medicine Department, Victor Babeş, National Institute of Pathology, Bucharest, Romania and Division of Cellular and Molecular Medicine, Carol Davila, University of Medicine and Pharmacy, Bucharest, Romania
Bruno Diaz Paredes Instituto de Biofísica Carlos Chagas Filho; Laboratório de Cardiologia Celular e Molecular; Programa de Terapia Celular e Bioengenharia; Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem -INBEB; Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
Paolo Pelosi Department of Surgical Sciences and Integrated Diagnostics, University of Genoa, Genoa, Italy
Fernando Pitossi Leloir Institute Foundation, Institute for Biochemical Investigations, CONICET, 1405 Buenos Aires, Argentina
L.M. Popescu Division of Advanced Studies, Victor Babeş, National Institute of Pathology, Bucharest, Romania
Patricia Rieken Macêdo Rocco Instituto de Biofísica Carlos Chagas Filho; Programa de Terapia Celular e Bioengenharia; Laboratório de Investigação Pulmonar; Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem -INBEB; Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
Isao Sakaida Division of Laboratory, Yamaguchi University Hospital, Yamaguchi University School of Medicine, Japan; Department of Gastroenterology and Hepatology, Yamaguchi University, Graduate School of Medicine Yamaguchi University, Japan
Marcelo F. Santiago Instituto de Biofísica Carlos Chagas Filho; Laboratório de Neurobiologia Celular e Molecular; Programa de Terapia Celular e Bioengenharia; Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem -INBEB; Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Eliana Scemes The Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, New York, New York,...
| Erscheint lt. Verlag | 31.12.2012 |
|---|---|
| Sprache | englisch |
| Themenwelt | Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie |
| Naturwissenschaften ► Biologie ► Zellbiologie | |
| Technik | |
| ISBN-10 | 0-12-391441-8 / 0123914418 |
| ISBN-13 | 978-0-12-391441-5 / 9780123914415 |
| Haben Sie eine Frage zum Produkt? |
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