Bioinorganic Chemistry (eBook)

ROSETTE M. ROAT-MALONE, PhD, is Professor of Chemistry at Washington College in Chestertown, Maryland. She received her doctorate in chemistry from the University of Delaware.

Preface.

Acknowledgments.

1 Inorganic Chemistry Essentials.

1.1 Introduction.

1.2 Essential Chemical Elements.

1.3 Metals in Biological Systems: A Survey.

1.4 Inorganic Chemistry Basics.

1.5 Biological Metal Ion Complexation.

1.6 Electronic and Geometric Structures of Metals in Biological Systems.

1.7 Bioorganometallic Chemistry.

1.8 Electron Transfer.

1.9 Conclusions.

References.

2 Biochemistry Fundamentals.

2.1 Introduction.

2.2 Proteins.

2.3 Nucleic Acids.

2.4 Zinc-Finger Proteins.

2.5 Conclusions.

References.

3 Instrumental and Computer-Based Methods.

3.1 Introduction.

3.2 X-Ray Absorption Spectroscopy (XAS) and Extended X-Ray Absorption Fine Structure (EXAFS).

3.3 X-Ray Crystallography.

3.4 Electron Paramagnetic Resonance.

3.5 Nuclear Magnetic Resonance.

3.6 Mo?ssbauer Spectroscopy.

3.7 Other Instrumental Methods.

3.8 Introduction to Computer-Based Methods.

3.9 Computer Hardware.

3.10 Molecular Modeling and Molecular Mechanics.

3.11 Quantum Mechanics-Based Computational Methods.

3.12 Computer Software for Chemistry.

3.13 World Wide Web Online Resources.

3.14 Summary and Conclusions.

References.

4 Iron-Containing Oxygen Carriers and Their Synthetic Models.

4.1 Introduction.

4.2 Myoglobin and Hemoglobin Basics.

4.3 Structure of the Prosthetic Group.

4.4 Analytical Techniques.

4.5 Mechanism for Reversible Binding of Dioxygen and Cooperativity of Oxygen Binding.

4.6 Behavior of Dioxygen Bound to Metals.

4.7 Structure of the Active Site in Myoglobin and Hemoglobin: Comparison to Model Compounds.

4.8 Model Compounds.

4.9 Binding of CO to Myoglobin, Hemoglobin, and Model Compounds.

4.10 Conclusions.

References.

5 Copper Enzymes.

5.1 Introduction, Occurrence, Structure, Function.

5.2 Discussion of Specific Enzymes.

5.3 Model Compounds.

5.4 Conclusions.

References.

6 The Enzyme Nitrogenase.

6.1 Introduction.

6.2 Detailed Mechanistic Studies.

6.3 Iron-Sulfur Clusters.

6.4 Fe-Protein Structure.

6.5 MoFe-Protein Structure.

6.6 Nitrogenase Model Compounds.

6.7 Conclusions.

References.

7 Metals in Medicine.

7.1 Introduction.

7.2 Therapeutic Compounds.

7.3 Diagnostic Agents.

7.4 Metal Transport and Metallochaperones.

7.5 Metals in Medicine (MIM).

References.

Index.

"...explain[s] the principle of bioinorganic chemistry and thenature of bioinorganic research in a lively and interesting way..."(Angewandte Chemie, Vol 42(48), 2003)

"...has the potential to stimulate interest and excitement inthe reader..."(The Biochemist, 12 March 2003)

"A must for any serious student of the topic...highlyrecommended..." (Choice, Vol. 40, No. 9, May 2003)

"...a valuable resource for workers in the field." (ClinicalChemistry, Vol. 49, No. 9, 2003)

"...a solid addition to the available textbooks for courses inbioinorganic chemistry..." (Quarterly Review of Biology,September/November 2003)