Chirality in Drug Research (eBook)
XIX, 351 Seiten
Wiley-VCH (Verlag)
978-3-527-60871-3 (ISBN)
The two editors from academia and a major pharmaceutical company have assembled an experienced, international team who provide first-hand practical advice and report previously unpublished data.
In the first section, the isolation of chiral drugs from natural sources, their production in enzymatic processes and the resolution of racemic mixtures in preparative chromatography are outlined in separate chapters. For the section on qualitative and quantitative analysis, enantioselective chromatographic methods are presented as well as optical methods and CE-MS, while the final section deals with the pharmacology, pharmacokinetics and metabolic aspects of chiral drugs, devoting whole chapters to stereoselective drug binding and modeling chiral drug-receptor interactions.
With its unique industry-relevant aspects, this is a must for medicinal and pharmaceutical chemists.
Eric Francotte received his BS and PhD degrees from the University of Louvain (Belgium). After postdoctoral work at the University of Geneva, he joined the Central Research Laboratories at Ciba-Geigy, where he was working on optically active polymers. He is now Director and Head of Separations at the Novartis Institutes for BioMedical Research in Basel (Switzerland). He is also an editor of the Wiley journal "Chirality". His major interests include development and applications of chiral stationary phases for the separation of stereoisomers on an analytical and preparative scale. Wolfgang Lindner received his PhD degree in Organic Chemistry from the University of Graz (Austria). After several academic positions, including a period at the FDA in Bethesda (USA), he was appointed the chair in Analytical Chemistry at the University of Vienna (Austria). He is also the editor of the Journal of Chromatography B, and the current president of the Austrian Society of Analytical Chemistry. His major interests lie in enantioselective separation techniques, including LC, CE, membranes, extractions, and in stereoselective pharmacokinetics.
INTRODUCTION
Chiral drugs from a historical point of view (J. Gal)
SYNTHESIS
Stereoselective synthesis of chiral drugs (H. Federsel)
Chiral drugs from natural source (F. Petersen)
Biotransformation methods for preparing chiral drugs and drug intermediates (M. Müller, M. Wubbolts)
SEPARATIONS
Resolution of chiral drugs and drug intermediates by crystallisation (K. Saigo)
Resolution of chiral drugs by preparative chromatography (E. Francotte)
ANALYSIS
Stereoselective chromatographic methods for drug analysis (W. Lindner)
CE-MS for the quantitative analysis of chiral drugs (J. Veuthey)
Spectrosopic methods for chiral drug analysis (N. Harada)
Modeling of chiral drug-receptor interactions (G. Folkers)
"... In general, the book has been welledited and produced and contains a useful subject index."
ChemMedChem
"...As appropriately stressed throughout the book, the several issues associated with chirality have emerged as major factors in drug design and development. This book is a timely and well written resource."
Journal of Medicinal Chemistry, 06/2007
"...Overall this is a useful book for process chemists working with chiral compounds in industry and the chapters highlighted in this review are recommended reading."
Organic Process Research and Development Journal, 08/2007
Erscheint lt. Verlag | 24.9.2007 |
---|---|
Reihe/Serie | Methods and Principles in Medicinal Chemistry |
Mitarbeit |
Herausgeber (Serie): Raimund Mannhold, Hugo Kubinyi, Gerd Folkers |
Sprache | englisch |
Themenwelt | Naturwissenschaften ► Chemie |
Technik | |
Schlagworte | Chemie • Chemistry • Chiralität (Chemie) • Chiralität (Chemie) • Chromatographie • Chromatographie / Trennverfahren • Chromatography / Separation Techniques • Drug Discovery & Development • Medical Science • Medizin • Medizinische Chemie • Natural Products • Naturstoffchemie • Organische Chemie • Pharmacology & Pharmaceutical Medicine • Pharmakologie • Pharmakologie u. Pharmazeutische Medizin • Wirkstoffforschung u. -entwicklung |
ISBN-10 | 3-527-60871-0 / 3527608710 |
ISBN-13 | 978-3-527-60871-3 / 9783527608713 |
Haben Sie eine Frage zum Produkt? |
![PDF](/img/icon_pdf_big.jpg)
Größe: 6,1 MB
Kopierschutz: Adobe-DRM
Adobe-DRM ist ein Kopierschutz, der das eBook vor Mißbrauch schützen soll. Dabei wird das eBook bereits beim Download auf Ihre persönliche Adobe-ID autorisiert. Lesen können Sie das eBook dann nur auf den Geräten, welche ebenfalls auf Ihre Adobe-ID registriert sind.
Details zum Adobe-DRM
Dateiformat: PDF (Portable Document Format)
Mit einem festen Seitenlayout eignet sich die PDF besonders für Fachbücher mit Spalten, Tabellen und Abbildungen. Eine PDF kann auf fast allen Geräten angezeigt werden, ist aber für kleine Displays (Smartphone, eReader) nur eingeschränkt geeignet.
Systemvoraussetzungen:
PC/Mac: Mit einem PC oder Mac können Sie dieses eBook lesen. Sie benötigen eine
eReader: Dieses eBook kann mit (fast) allen eBook-Readern gelesen werden. Mit dem amazon-Kindle ist es aber nicht kompatibel.
Smartphone/Tablet: Egal ob Apple oder Android, dieses eBook können Sie lesen. Sie benötigen eine
Geräteliste und zusätzliche Hinweise
Buying eBooks from abroad
For tax law reasons we can sell eBooks just within Germany and Switzerland. Regrettably we cannot fulfill eBook-orders from other countries.
aus dem Bereich