Chirality in Drug Research
Wiley-VCH (Verlag)
978-3-527-31076-0 (ISBN)
Eric Francotte received his BS and PhD degrees from the University of Louvain (Belgium). After postdoctoral work at the University of Geneva, he joined the Central Research Laboratories at Ciba-Geigy, where he was working on optically active polymers. He is now Director and Head of Separations at the Novartis Institutes for BioMedical Research in Basel (Switzerland). He is also an editor of the Wiley journal "Chirality". His major interests include development and applications of chiral stationary phases for the separation of stereoisomers on an analytical and preparative scale. Wolfgang Lindner received his PhD degree in Organic Chemistry from the University of Graz (Austria). After several academic positions, including a period at the FDA in Bethesda (USA), he was appointed the chair in Analytical Chemistry at the University of Vienna (Austria). He is also the editor of the Journal of Chromatography B, and the current president of the Austrian Society of Analytical Chemistry. His major interests lie in enantioselective separation techniques, including LC, CE, membranes, extractions, and in stereoselective pharmacokinetics.
INTRODUCTION
Chiral drugs from a historical point of view (J. Gal)
SYNTHESIS
Stereoselective synthesis of chiral drugs (H. Federsel)
Chiral drugs from natural source (F. Petersen)
Biotransformation methods for preparing chiral drugs and drug intermediates (M. Müller, M. Wubbolts)
SEPARATIONS
Resolution of chiral drugs and drug intermediates by crystallisation (K. Saigo)
Resolution of chiral drugs by preparative chromatography (E. Francotte)
ANALYSIS
Stereoselective chromatographic methods for drug analysis (W. Lindner)
CE-MS for the quantitative analysis of chiral drugs (J. Veuthey)
Spectrosopic methods for chiral drug analysis (N. Harada)
Modeling of chiral drug-receptor interactions (G. Folkers)
"... In general, the book has been welledited and produced and contains a useful subject index."
ChemMedChem
"...As appropriately stressed throughout the book, the several issues associated with chirality have emerged as major factors in drug design and development. This book is a timely and well written resource."
Journal of Medicinal Chemistry, 06/2007
"...Overall this is a useful book for process chemists working with chiral compounds in industry and the chapters highlighted in this review are recommended reading."
Organic Process Research and Development Journal, 08/2007
Erscheint lt. Verlag | 21.9.2006 |
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Reihe/Serie | Methods and Principles in Medicinal Chemistry ; 33 |
Mitarbeit |
Herausgeber (Serie): Raimund Mannhold, Hugo Kubinyi, Gerd Folkers |
Sprache | englisch |
Maße | 170 x 240 mm |
Gewicht | 824 g |
Themenwelt | Medizin / Pharmazie ► Pharmazie |
Naturwissenschaften ► Chemie | |
Schlagworte | Arzneimittelchemie • Chemie • Chemistry • Chiralität • Chiralität (Chemie) • Chromatographie • Chromatographie / Trennverfahren • Chromatography / Separation Techniques • Drug Discovery & Development • Drug Discovery & Development • Medical Science • Medizin • Medizinische Chemie • Medizinische Forschung • Natural Products • Naturstoffchemie • Organische Chemie • Pharmacology & Pharmaceutical Medicine • Pharmacology & Pharmaceutical Medicine • Pharmakologie • Pharmakologie u. Pharmazeutische Medizin • Wirkstoffforschung u. -entwicklung |
ISBN-10 | 3-527-31076-2 / 3527310762 |
ISBN-13 | 978-3-527-31076-0 / 9783527310760 |
Zustand | Neuware |
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