Boronic Acids (eBook)

Dennis Hall is a Professor of Chemistry at the University of Alberta (Edmonton, Canada). He was born in 1968 in northern Quebec, Canada, and was educated at Université de Sherbrooke, obtaining his Ph.D. in 1995 under the direction of Prof. Pierre Deslongchamps. Hall was an NSERC Postdoctoral Fellow in the laboratory of Prof. Peter G. Schultz in the Department of Chemistry at the University of California, Berkeley, and initiated his independent career in 1997. The unifying theme of his research program is the development of new synthetic and biological applications of organoboronic acid derivatives. Ongoing projects in his laboratory cover a wide range of topics, including stereocontrolled allylation methodology, multicomponent reactions, solid-phase organic synthesis, combinatorial chemistry and oligosaccharide recognition. His recent awards include a Petro-Canada Young Innovator Award (2003), the AstraZeneca Award in Chemistry (2003), and the University of Alberta's Martha Cook Piper Research Prize (2004). He is a Fellow of the Canadian Institute of Chemistry.

Structure, properties, and preparation of boronic acid derivatives. Overview of their reactions and applications.
Metal-catalyzed borylation of alkanes and arenas via C-H activation for synthesis of boronic esters.
Coupling reactions of areneboronic acids or esters with aromatic electrophiles.
Rhodium-catalyzed additions of boronic acids to alkenes and carbonyl compounds.
Copper-promoted C-O and C-N cross-coupling of boronic acids.
Preparation of allylboronates and recent applications in organic synthesis.
Nulceophilic addition reactions of aryl and akenylboronic acids and their derivatives to imines and iminium ions.
Alpha-haloalkylboronic esters in asymmetric synthesis.
Cycloadditions and other additions to alkenyl- alkynyl-, and dienylboronic esters.
Organoboronic acids and organoborinic acids as Bronsted-Lewis acid catalysts in organic synthesis.
Oxazaborolidines as asymmetric inducers for the reduction of ketones and ketimines.
Boronic acid based receptors and sensors for saccharides.
Biological and medicinal applications of boronic acids.
Structure, properties, and preparation of boronic acid derivatives. Overview of their reactions and applications.
Metal-catalyzed borylation of alkanes and arenas via C-H activation for synthesis of boronic esters.
Coupling reactions of areneboronic acids or esters with aromatic electrophiles.
Rhodium-catalyzed additions of boronic acids to alkenes and carbonyl compounds.
Copper-promoted C-O and C-N cross-coupling of boronic acids.
Preparation of allylboronates and recent applications in organic synthesis.
Nulceophilic addition reactions of aryl and akenylboronic acids and their derivatives to imines and iminium ions.
Alpha-haloalkylboronic esters in asymmetric synthesis.
Cycloadditions and other additions to alkenyl- alkynyl-, and dienylboronic esters.
Organoboronic acids and organoborinic acids as Bronsted-Lewis acid catalysts in organic synthesis.
Oxazaborolidines as asymmetric inducers for the reduction of ketones and ketimines.
Boronic acid based receptors and sensors for saccharides.
Biological and medicinal applications of boronic acids.

"Overall, Hall's book provides an excellent starting point from which to explore the chemistry of boronic acids, but also one which gives a perspective on likely future developments. A clear positive feedback loop emerges from the material herein, whereby the take-up of new reactions and applications leads to demands for improved methods for the preparation of boronate substrates which in turn offers wider scope for further new reactivity patterns to be exploited. Hall states at the outset that his task was to provide the first comprehensive book on the chemistry and biology of boronic acids; this he has done, but at the pace of current developments, a second edition might not be so long in arriving."
Angewandte Chemie IE

"For some reason, this excellent book didn't get reviewed as soon as it was published but we would like to remedy this now...In conclusion, this excellent book deserves to be on the bookshelf of all synthetic chemists, whether in discovery or process chemistry."
Organic Process Research & Development Journal

"Da die synthetische Nützlichkeit von Boronsäuren und Derivaten im Buch eindrücklich beschrieben wird, erhält der Leser auf jeden Fall einigen Benefit für eigene Ideen, auch wenn er nicht sofort alle präsentierten Reaktionstypen nutzt."
http://www.organische-chemie.ch/

"...eine hervorragende Monographie zur Chemie der Boronsäuren, die geeignet ist, den Forschungen auf diesem Gebiet neue Impulse zu verleihen. Es war das erklärte Ziel des Herausgebers, die erste umfassende Monographie über die Chemie und biologischen Eigenschaften von Boronsäuren vorzulegen. Dies ist ihm hervorragend gelungen, und angesichts der rasanten Entwicklungen auf diesem Gebiet wird wohl bald eine zweite Ausgabe folgen."
Angewandte Chemie