Adult Stem Cells (eBook)
XI, 279 Seiten
Humana Press (Verlag)
978-1-61779-002-7 (ISBN)
This is comprehensive overview of a vital area of scientific enquiry, which covers a broad spectrum of issues. With contributions from some of the key researchers in the field, Adult Stem Cells: Biology and Methods of Analysis offers readers a historical perspective as well as unique insights into cutting-edge thoughts. The volume contextualizes the recent discovery of stem/progenitor cell populations resident in many adult tissues and organs. It confronts the complexities scientists face in trying to validate these cells, while it also describes and critically evaluates the methods currently used to assess stem cell self-renewal. The chapters also seek to distinguish this process from other aspects of cell survival, such as the regulation of life span, senescence, and immortalization at a molecular level.
The monograph begins with a section that examine the basic biology of adult stem cells, including chapters on the emerging role of microRNAs in regulating their fate and the molecular mechanisms that govern their self-renewal, the book moves on to analyze the varying methodologies employed in characterizing these elusive elements of our genetic make-up. The second section details in-vivo lineage tracing of tissue-specific stem cells, explores the neural stem cell paradigm, and considers the function of ABC transporters and aldehyde dehydrogenase in adult stem-cell biology. The final section shifts the focus to the life-span regulation and immortalization and features a chapter on the cancer stem cell paradigm.
This is an authoritative volume on one of the frontiers of genetic research, and will serve as a valuable resource, not just for established scientists but also for those now entering the field of stem cell biology.
This is comprehensive overview of a vital area of scientific enquiry, which covers a broad spectrum of issues. With contributions from some of the key researchers in the field, Adult Stem Cells: Biology and Methods of Analysis offers readers a historical perspective as well as unique insights into cutting-edge thoughts. The volume contextualizes the recent discovery of stem/progenitor cell populations resident in many adult tissues and organs. It confronts the complexities scientists face in trying to validate these cells, while it also describes and critically evaluates the methods currently used to assess stem cell self-renewal. The chapters also seek to distinguish this process from other aspects of cell survival, such as the regulation of life span, senescence, and immortalization at a molecular level. The monograph begins with a section that examine the basic biology of adult stem cells, including chapters on the emerging role of microRNAs in regulating their fate and the molecular mechanisms that govern their self-renewal, the book moves on to analyze the varying methodologies employed in characterizing these elusive elements of our genetic make-up. The second section details in-vivo lineage tracing of tissue-specific stem cells, explores the neural stem cell paradigm, and considers the function of ABC transporters and aldehyde dehydrogenase in adult stem-cell biology. The final section shifts the focus to the life-span regulation and immortalization and features a chapter on the cancer stem cell paradigm.This is an authoritative volume on one of the frontiers of genetic research, and will serve as a valuable resource, not just for established scientists but also for those now entering the field of stem cell biology.
Preface Contributors Corresponding Authors Part I Basic Biology of Adult Stem Cells Chapter 1 Molecular Mechanisms Regulating Adult Stem Cell Self-Renewal D. M. Panchision Chapter 2 Maintenance of Adult Stem Cells: Role of the Stem Cell Niche T. SudaChapter 3 Emerging Role for microRNAs in Regulating Adult Stem Cell Fate J.M. Shookhoff and G.I. GallicanoChapter 4 Expression and Function of Pluripotency-Specific Genes in Adult Stem Cells A. Lo Nigro, P. Roelandt and C. M. Verfaillie Chapter 5 Adult Stem Cell Plasticity Revisited E. Mezey Part II Characterization of Adult Stem CellsChapter 6 Lineage Tracing of Tissue-Specific Stem Cells In Vivo K. T. Sobush, K. Matsumoto, H. Chen, and B. R.Stripp Chapter 7 Surrogate Measure of Adult Stem Cells Self- Rewal: The Neural Stem Cell Paradigm L.P. Deleyrolle, B.A. Reynolds and F.A. Siebzehnrubl Chapter 8 ABC Transporters, Aldehyde Dehydrogenase, And Adult Stem Cells M. R. Allison Part III Regulation of Life Span and ImmortalizationChapter 9 Regulation of Life Span in Adult Stem Cells P. Davy and R. AllsoppChapter 10 The cancer stem cell paradigm C. Eyler, J. Heddleston, S. Rhinos, M. Hitomi, O. Guryanova, W. Flavahan, A. Hjelmeland, and J. Rich
Erscheint lt. Verlag | 11.2.2011 |
---|---|
Reihe/Serie | Stem Cell Biology and Regenerative Medicine | Stem Cell Biology and Regenerative Medicine |
Zusatzinfo | XI, 279 p. |
Verlagsort | Totowa |
Sprache | englisch |
Themenwelt | Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie |
Naturwissenschaften ► Biologie ► Zellbiologie | |
Technik ► Umwelttechnik / Biotechnologie | |
Schlagworte | adult stem cell biology • miRNA • pluripotency genes • Stem Cells |
ISBN-10 | 1-61779-002-8 / 1617790028 |
ISBN-13 | 978-1-61779-002-7 / 9781617790027 |
Haben Sie eine Frage zum Produkt? |
![PDF](/img/icon_pdf_big.jpg)
Größe: 5,9 MB
DRM: Digitales Wasserzeichen
Dieses eBook enthält ein digitales Wasserzeichen und ist damit für Sie personalisiert. Bei einer missbräuchlichen Weitergabe des eBooks an Dritte ist eine Rückverfolgung an die Quelle möglich.
Dateiformat: PDF (Portable Document Format)
Mit einem festen Seitenlayout eignet sich die PDF besonders für Fachbücher mit Spalten, Tabellen und Abbildungen. Eine PDF kann auf fast allen Geräten angezeigt werden, ist aber für kleine Displays (Smartphone, eReader) nur eingeschränkt geeignet.
Systemvoraussetzungen:
PC/Mac: Mit einem PC oder Mac können Sie dieses eBook lesen. Sie benötigen dafür einen PDF-Viewer - z.B. den Adobe Reader oder Adobe Digital Editions.
eReader: Dieses eBook kann mit (fast) allen eBook-Readern gelesen werden. Mit dem amazon-Kindle ist es aber nicht kompatibel.
Smartphone/Tablet: Egal ob Apple oder Android, dieses eBook können Sie lesen. Sie benötigen dafür einen PDF-Viewer - z.B. die kostenlose Adobe Digital Editions-App.
Buying eBooks from abroad
For tax law reasons we can sell eBooks just within Germany and Switzerland. Regrettably we cannot fulfill eBook-orders from other countries.
aus dem Bereich