Heart Development and Regeneration -

Heart Development and Regeneration (eBook)

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2010 | 1. Auflage
1136 Seiten
Elsevier Science (Verlag)
978-0-12-381333-6 (ISBN)
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The development of the cardiovascular system is a rapidly advancing area in biomedical research, now coupled with the burgeoning field of cardiac regenerative medicine. A lucid understanding of these fields is paramount to reducing human cardiovascular diseases of both fetal and adult origin. Significant progress can now be made through a comprehensive investigation of embryonic development and its genetic control circuitry. Heart Development and Regeneration, written by experts in the field, provides essential information on topics ranging from the evolution and lineage origins of the developing cardiovascular system to cardiac regenerative medicine. A reference for clinicians, medical researchers, students, and teachers, this publication offers broad coverage of the most recent advances. Volume One discusses heart evolution, contributing cell lineages; model systems; cardiac growth; morphology and asymmetry; heart patterning; epicardial, vascular, and lymphatic development; and congenital heart diseases. Volume Two includes chapters on transcription factors and transcriptional control circuits in cardiac development and disease; epigenetic modifiers including microRNAs, genome-wide mutagenesis, imaging, and proteomics approaches; and the theory and practice of stem cells and cardiac regeneration. - Authored by world experts in heart development and disease - New research on epigenetic modifiers in cardiac development - Comprehensive coverage of stem cells and prospects for cardiac regeneration - Up-to-date research on transcriptional and proteomic circuits in cardiac disease - Full-color, detailed illustrations
The development of the cardiovascular system is a rapidly advancing area in biomedical research, now coupled with the burgeoning field of cardiac regenerative medicine. A lucid understanding of these fields is paramount to reducing human cardiovascular diseases of both fetal and adult origin. Significant progress can now be made through a comprehensive investigation of embryonic development and its genetic control circuitry. Heart Development and Regeneration, written by experts in the field, provides essential information on topics ranging from the evolution and lineage origins of the developing cardiovascular system to cardiac regenerative medicine. A reference for clinicians, medical researchers, students, and teachers, this publication offers broad coverage of the most recent advances. Volume One discusses heart evolution, contributing cell lineages; model systems; cardiac growth; morphology and asymmetry; heart patterning; epicardial, vascular, and lymphatic development; and congenital heart diseases. Volume Two includes chapters on transcription factors and transcriptional control circuits in cardiac development and disease; epigenetic modifiers including microRNAs, genome-wide mutagenesis, imaging, and proteomics approaches; and the theory and practice of stem cells and cardiac regeneration. - Authored by world experts in heart development and disease- New research on epigenetic modifiers in cardiac development- Comprehensive coverage of stem cells and prospects for cardiac regeneration- Up-to-date research on transcriptional and proteomic circuits in cardiac disease- Full-color, detailed illustrations

List of Contributors


Number in parentheses indicates the chapter to which the author contributed.

Jeffrey D. Amack (4.1), Department of Cell and Developmental Biology, SUNY Upstate Medical University, Syracuse, NY 13210

Brad A. Amendt (4.3), Institute of Biosciences and Technology, Texas A&M System Health Science Center, 2121 Holcombe Blvd, Houston, TX 77030

Robert H. Anderson (3.2, 3.4), Cardiac Unit, Institute of Child Health, University College, London, UK

Piero Anversa (14.3), Cardiovascular Research Institute, Departments of Medicine, New York Medical College, Valhalla, NY 10595

Ana Paula Azambuja (1.1), Laboratório de Genética e Cardiologia Molecular, Instituto do Coração, Faculdade de Medicina, Universidade de São Paulo, São Paulo-SP, Brazil; and Departamento de Biologia Celular e do Desenvolvimento, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo-SP, Brazil

David Bader (1.5), Stahlman Cardiovascular Research Laboratories, Program for Developmental Biology, and Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232-2561

Shoumo Bhattacharya (11.3), Wellcome Trust Centre for Human Genetics, University of Oxford, UK

Brian L. Black (9.5), Cardiovascular Research Institute and Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158-2517

Daniel G. Blackmore (13.1), Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, 4072, Australia

Rolf Bodmer (1.2), Development and Aging Program, NASCR Center, Burnham Institute for Medical Research, 10901 North Torrey Pines Rd, La Jolla, CA 92037

Thomas Brand (5.1), Heart Science Centre, National Heart and Lung Institute, Imperial College London, UK

Marianne Bronner-Fraser (7.1), California Institute of Technology, Pasadena, CA 91125

Nigel A. Brown (3.4, 4.3), Division of Basic Medical Sciences, St George’s University of London, Cranmer Terrace, London SW17 0RE, UK

Benoit G. Bruneau (10.1), Gladstone Institute of Cardiovascular Disease and Department of Pediatrics, University of California, San Francisco, CA 94158

Margaret E. Buckingham (3.1), Department of Developmental Biology, CNRS URA2578, Pasteur Institute, 25 rue du Dr Roux, Paris, France

Todd D. Camenisch (6.1), Departments of Pharmacology and Toxicology, Molecular and Cellular Biology, Steele Children’s Research Center, Bio5 Institute, University of Arizona, Tucson, AZ

Hozana Andrade Castillo (1.1), Laboratório de Genética e Cardiologia Molecular, Instituto do Coração, Faculdade de Medicina, Universidade de São Paulo, São Paulo-SP, Brazil; and Departamento de Biologia Celular e do Desenvolvimento, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo-SP, Brazil

Rodrigo Abe Castro (1.1), Laboratório de Genética e Cardiologia Molecular, Instituto do Coração, Faculdade de Medicina, Universidade de São Paulo, São Paulo-SP, Brazil; and Departamento de Biologia Celular e do Desenvolvimento, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo-SP, Brazil

Bishwanath Chatterjee (11.2), Laboratory of Developmental Biology, National Heart Lung Blood Institute, National Institutes of Health, Bethesda, MD 20892

Vincent M. Christoffels (2.3, 3.2), Heart Failure Research Center, Academic Medical Center, Amsterdam, The Netherlands

Ondine Cleaver (8.2), Dept. of Molecular Biology NA8.300, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390

Frank L. Conlon (9.4), Department of Genetics, Fordham Hall, University of North Carolina-Chapel Hill, Chapel Hill, NC 27599

Kimberly R. Cordes (10.3), Gladstone Institute of Cardiovascular Disease and Departments of Pediatrics, Biochemistry and Biophysics, University of California, San Francisco, 1650 Owens Street, San Francisco, CA 94158

David M. Cox (11.5), MDS Sciex 71 Four Valley Drive, Concord, Ontario, Canada L4K 4V8

Richard M. Cripps (9.5), Department of Biology, University of New Mexico, Albuquerque, NM 87131-0001

Brad Davidson (1.1), Department of Molecular and Cell Biology, Division of Genetics and Development, Center for Integrative Genomics, University of California, Berkeley, CA 94720

José Luis de la Pompa (6.2), Departamento de Biología del Desarrollo Cardiovascular, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Melchor Fernández Almagro 3, E-28029 Madrid, Spain

Stefanie Dimmeler (14.2) Professor of Medicine, Molecular Cardiology, Department of Internal Medicine III, University of Frankfurt, Theodor-SternKai 7, 60590 Frankfurt, Germany

Pascal Dollé (3.3), Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), BP 10142, Illkirch, F-67400 France; Inserm, U 964, Illkirch, F-67400 France; CNRS, UMR 7104, Illkirch, F-67400 France; Université de Strasbourg, Faculté de Médecine, Strasbourg, F-67000 France

Min Du (11.5), Department of Biology, York University, Toronto, Ontario, Canada, M3J 1P3

Victor J. Dzau (14.1), Molecular and Genomic Vascular Biology, Duke University Medical Center, DUMC 3701, Durham, NC 27710

David A. Elliott (9.1), Monash Immunology and Stem Cell Laboratories, Monash University, Clayton, Victoria, 3800, Australia

Sylvia M. Evans (2.2), Skaggs School of Pharmacy and Pharmaceutical Sciences, and Department of Medicine, University of San Diego, La Jolla, CA

Max Ezin (7.1), California Institute for Technology, Pasadena, CA 91125

Ann C. Foley (1.3), Divison of Cardiology, Weill Cornell Medical College, New York, NY 10065

Richard Francis (11.2), Laboratory of Developmental Biology, National Heart Lung Blood Institute, National Institutes of Health, Bethesda, MD 20892

Manfred Frasch (1.2), Department of Biology, Developmental Biology Unit, University of Erlangen-Nürnberg, Erlangen, Staudtstr. 5, 91058, Germany

Daniel J. Garry (11.1), Lillehei Heart Institute, and Department of Internal Medicine, University of Minnesota, Minneapolis, MN 55455

Lior Gepstein (13.2), The Sohnis Family Research Laboratory for the Regeneration of Functional Myocardium, Department of Biophysics and Physiology, the Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel

Massimiliano Gnecchi (14.1), Department of Cardiology, Fondazione I.R.C.C.S. Policlinico San Matteo, University of Pavia, Viale Golgi 19, 27100, Pavia, Italy

Joseph Gold (13.2), Geron Corporation, Menlo Park, CA 94025

Joaquim Grego-Bessa (6.2), Sloan-Kettering Institute, 1275 York Ave., New York, NY 10065

Thomas Gridley (8.3), The Jackson Laboratory, Bar Harbor, ME

Rosa M. Guzzo (1.3), Department of Orthopedic Surgery, University of Connecticut Health Center, Farmington, CT 06034

Hiroshi Hamada (4.2), Developmental Genetics Group, Graduate School for Frontier Biosciences, Osaka University; and CREST, Japan Science and Technology Corporation (JST), 1-3 Yamada-oka, Suita, Osaka 565-0871, Japan

Natasha L. Harvey (8.4), Division of Haematology, The Centre for Cancer Biology, SA Pathology, Adelaide, South Australia, Australia

Richard P. Harvey (9.1), Victor Chang Cardiac Research Institute, Sydney, NSW, 2010, Australia and Faculties of Science and Medicine, University of New South Wales, Kensington, 2053, Australia

Steve Hauschka (11.4), Department of Biochemistry, University of Washington, Seattle, Washington, 98195

Charis Himeda (11.4), Department of Biochemistry, University of Washington, Seattle, Washington, 98195

Willem M. H. Hoogaars (2.3), Heart Failure Research Center, Academic Medical Center, Amsterdam, The Netherlands

Guo-Ying Huang (11.2), Pediatric Heart Center, Children’s Hospital of Fudan University, Shanghai, China

Mary R. Hutson (7.2), Department of Pediatrics (Neonatology), Neonatal-Perinatal Research Institute, Jones Building, Room 401, Box 103105, Duke University Medical Center, Durham, NC 27710

Kimberly E. Inman (7.1), Stowers Institute for Medical Research, 1000 E. 50th Street, Kansas City, MO 64110

Silviu Itescu (14.2), Director of Transplantation Immunology, Columbia University Medical Center, 630 West 168th Street, New York, NY 10032; Columbia University College of Physicians and Surgeons, and Professor of Medicine, University of Melbourne, Melbourne, Australia

Jan Kajstura (14.3), Cardiovascular Research Institute, Departments of Medicine, New York Medical College, Valhalla, NY 10595

Robert G. Kelly (2.2), Developmental Biology Institute of...

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