The first three editions of this book developed a reputation as the leading reference in cardiovascular science for researchers and academic cardiologists. This recent edition has been updated, expanded, and includes a number of new contributors. It has also been remodeled to expand its usage as a text reference for cardiology residents, practicing cardiologists, and graduate students.
Key Features
* The most comprehensive book available on this topic
* Clear, concise, and complete coverage of all important aspects of cardiovascular physiology/pathophysiology
* Completely updated version of the foremost reference on cardiovascular science, including new information on pathophysiology and electrophysiology
* Useful tool in bridging the gap between basic science, pathophysiology, and clinical cardiology
Heart Physiology and Pathophysiology, 4E, provides the foundation for the scientific understanding of heart function and dysfunction, and bridges the gap between basic cardiovascular science and clinical cardiology. This comprehensive text covers all the important aspects of the heart and vascular system. The most important and relevant disorders are presented, with emphasis on the mechanisms involved. The first three editions of this book developed a reputation as the leading reference in cardiovascular science for researchers and academic cardiologists. This recent edition has been updated, expanded, and includes a number of new contributors. It has also been remodeled to expand its usage as a text reference for cardiology residents, practicing cardiologists, and graduate students.Key Features* The most comprehensive book available on this topic* Clear, concise, and complete coverage of all important aspects of cardiovascular physiology/pathophysiology* Completely updated version of the foremost reference on cardiovascular science, including new information on pathophysiology and electrophysiology* Useful tool in bridging the gap between basic science, pathophysiology, and clinical cardiology
Front Cover 1
Heart Physiology and Pathophysiology 4
Copyright Page 5
Contents 8
Contributors 14
Foreword 20
Preface 22
PART I: PUMPING ACTION AND ELECTRICAL ACTIVITY OF THE HEART 24
Chapter 1. Sequence of Cardiac Activation and Ventricular Mechanics 26
Chapter 2. Coronary Circulation and Hemodynamics 42
Chapter 3. Neurohumoral Control of Cardiac Function 68
Chapter 4. Control of Cardiac Output and its Alterations during Exercise and in Heart Failure 84
Chapter 5. Ultrastructure of Cardiac Muscle and Blood Vessels 94
Chapter 6. Excitability and Impulse Propagation 122
Chapter 7. Electrocardiogram and Cardiac Excitation 156
Chapter 8. Gap-Junction Channels and Healing-Over of Injury 172
PART II: CELLULAR ELECTROPHYSIOLOGY OF HEART AND VASCULAR SMOOTH MUSCLE 196
Chapter 9. Electrogenesis of the Resting Potential 198
Chapter 10. Cardiac Action Potentials 222
Chapter 11. Electrophysiology of Vascular Smooth Muscle 236
Chapter 12. Sodium Channels 252
Chapter 13. Voltage-Dependent Calcium Channels 270
Chapter 14. Voltage-Dependent K+ Channels 282
Chapter 15. Inwardly-Rectifying K+ Channels in the Heart 304
Chapter 16. Voltage and Calcium-Activated K+ Channels of Coronary Smooth Muscle 332
Chapter 17. Ion Channels in Vascular Smooth Muscle 350
Chapter 18. Cardiac Pacemaker Currents 380
Chapter 19. Chloride Channels in Heart 396
Chapter 20. Regulation of Cardiac Ion Channels by Phosphorylation, Ca2+, Cytoskeleton, and Stretch 412
PART III: PUMPS AND EXCHANGERS 428
Chapter 21. Cardiac Na+/K+ Pump 430
Chapter 22. Cardiac Na+ -Ca2+ Exchanger: Pathophysiology and Pharmacology 440
Chapter 23. Na+/H+ Exchanger and pH Regulation 450
Chapter 24. Transport in Nucleus 460
Chapter 25. Sarcoplasmic Reticulum Ca2+ Transport 470
Chapter 26. Calcium Release from Cardiac Sarcoplasmic Reticulum 484
PART IV: VASCULAR ENDOTHELIUM 494
Chapter 27. Function of Vascular Endothelium 496
Chapter 28. Ion Channels in Vascular Endothelium 504
PART V: EXCITATION–CONTRACTION COUPLING AND PHARMACOMECHANICAL COUPLING 522
Chapter 29. Electromechanical and Pharmacomechanical Coupling in Vascular Smooth Muscle Cells 524
Chapter 30. Mechanisms Regulating Cardiac Myofilament Response to Calcium 542
Chapter 31. Vascular Smooth Muscle Contraction 550
PART VI: METABOLISM AND ENERGETICS 564
Chapter 32. Myocardial Energy Metabolism 566
Chapter 33. Metabolism and Energetics of Vascular Smooth Muscle 594
PART VII: SIGNALING SYSTEMS 620
Chapter 34. Adrenergic Receptors in the Cardiovascular System 622
Chapter 35. Cardiac Action of Angiotensin II 632
Chapter 36. ATP and Adenosine Signal Transductions 656
Chapter 37. Kinase Signaling in the Cardiovascular System 680
Chapter 38. Calcium Signaling 702
Chapter 39. Diadenosine Polyphosphate Signaling in the Heart 716
PART VIII: DEVELOPMENTAL CHANGES AND AGING 726
Chapter 40. Cardiac Development and Regulation of Cardiac Transcription 728
Chapter 41. Developmental Changes of Ion Channels 742
Chapter 42. Aging of the Cardiovascular System 760
Chapter 43. Changes in Autonomic Responsiveness during Development 784
PART IX: MECHANISM OF ACTION OF CARDIOACTIVE DRUGS 800
Chapter 44. Inotropic Mechanism in Cardiac Muscle 802
Chapter 45. Mechanisms of Action of Calcium Antagonists 812
Chapter 46. Cyclic Nucleotides and Protein Phosphorylation in Vascular Smooth Muscle Relaxation 828
Chapter 47. K+ Channel Openers 852
Chapter 48. Mode of Action of Antiarrhythmic Drugs 860
PART X: PATHOPHYSIOLOGY 874
Chapter 49. Cellular Mechanisms of Cardioprotection 876
Chapter 50. Ischemic Preconditioning: Description, Mechanism, and Significance 890
Chapter 51. Cardioplegia and Surgical Ischemia 910
Chapter 52. Apoptosis 950
Chapter 53. Calcium Overload in Ischemia/Reperfusion Injury 972
Chapter 54. Coronary Atherosclerosis and Restenosis 990
Chapter 55. Diabetic Vascular Disease 1034
Chapter 56. Angiogenesis and Coronary Collateral Circulation 1054
Chapter 57. Molecular Pathophysiology of Cardiomyopathies 1068
Chapter 58. Signal Transduction of Cardiac Myocyte Hypertrophy 1088
Chapter 59. Electrophysiological Changes in Hypertrophy 1110
Chapter 60. Molecular Basis of Inherited Long QT Syndromes and Cardiac Arrhythmias 1120
Chapter 61. Molecular Mechanisms of Atrial Fibrillation 1130
Chapter 62. Lipids Released during Ischemia and Arrhythmogenesis 1148
Chapter 63. Ion Channels in the Heart 1160
Chapter 64. Cardiac Arrhythmias: Reentry and Triggered Activity 1176
Chapter 65. Myocardial Reperfusion Injury—Role of Free Radicals and Mediators of Inflammation 1204
Chapter 66. Cardiac Toxicology 1234
Chapter 67. Regulation of Gene Expression by Hypoxia 1248
Chapter 68. Gene Transfer in Cardiovascular Therapy 1256
Index 1268
Color Plate Section 1286
Contributors
The numbers in parentheses indicate the pages on which the authors’ contributions begin.
Jun-ichi Abe(657)
Cardiovascular Research Center, University of Rochester Medical Center, Rochester, New York 14642
Hugues Abriel(1137)
Department of Pharmacology, Columbia University, New York, New York 10032
Eric A. Accili(357)
School of Kinesiology, Faculty of Applied Sciences, Simon Fraser University, Burnaby, British Columbia, Canada V5A 1S6
Daniel Acosta, Jr. (1211)
College of Pharmacy, University of Cincinnati, Cincinnati, Ohio 45267
Lee F. Allen(599)
Department of Early Clinical Research, Pfizer, Inc., Groton, Connecticut 06340
Tara J. Allen(571)
Department of Physiology, University of Missouri, Columbia, Missouri 65212
Charles Antzelevitch(1153)
Masonic Medical Research Laboratory, Utica, New York 13501
Hiroki Aoki(1065)
Cardiovascular Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215
Jeffrey L. Ardell(45)
Department of Pharmacology, James H. Quillen College of Medicine, Johnson City, Tennessee 37614
Makoto Arita(229)
Department of Physiology, Oita Medical University, Oita 879-5593, Japan
Morton F. Arnsdorf(99)
Department of Medicine, Section of Cardiology, University of Chicago, Chicago, Illinois 60637
John A. Auchampach(633)
Department of Medicine, University of Louisville, Louisville, Kentucky 40292
Shmuel Banai(967)
Department of Cardiology, Bikur Cholim Hospital, and Department of Anatomy and Cell Biology, The Hebrew University, Hadassah Medical School, Jerusalem 91120, Israel
Jacques Barhanin(1097)
Institut de Pharmacologie Moléculaire et Cellulaire, Sophia Antipolis, 06560 Valbonne, France
M. Baruscotti(357)
Department of Physiology and General Biochemistry, University of Milan, 20133 Milan, Italy
Brian M. Bennett(805)
Departments of Pharmacology and Toxicology, Faculty of Medicine, Queen’s University, Kingston, Ontario, Canada K7L 3N6
Bradford C. Berk(657)
Cardiovascular Research Center, University of Rochester Medical Center, Rochester, New York 14642
Donald M. Bers(779)
Department of Physiology, Loyola University Chicago, Maywood, Illinois 60153
Marvin Boluyt(737)
Department of Movement Science, Laboratory of Molecular Kinesiology, University of Michigan, Ann Arbor, Michigan 48109
Mulugu V. Brahmajothi(259)
Department of Physiology and Biophysics, University at Buffalo, State University of New York, Buffalo, New York 14214
Eugene Braunwald(xix)
Department of Medicine, Brigham & Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115
Alexander Burashnikov(1153)
Masonic Medical Research Laboratory, Utica, New York 13501
Donald L. Campbell(259)
Department of Physiology and Biophysics, University at Buffalo, State University of New York, Buffalo, New York 14214
D.J. Chambers(887)
Cardiac Surgical Research/Cardiothoracic Surgery, Guy’s and St. Thomas’ NHS Trust, The Rayne Institute, King’s College, St. Thomas’ Hospital, London SE1 7EH, England
Frédéric Charron(705)
Laboratory of Cardiac Growth and Differentiation, Montreal Clinical Research Institute, and Department of Medicine, Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada H2W 1R7
Vijay S. Chauhan(837)
Duke University Medical Center, Durham, North Carolina 27710
University of Western Ontario, Ontario, Canada
Guoxiang Chu(447)
Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267
Michael V. Cohen(867)
Departments of Medicine and Physiology, University of South Alabama, College of Medicine, Mobile, Alabama 36688
Humbert De Smedt(501)
Department of Physiology, Catholic University of Leuven, B-3000 Leuven, Belgium
Naranjan S. Dhalla(949)
Institute of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, and Department of Physiology
Faculty of Medicine, University of Manitoba, Winnipeg, Canada R2H 2A6
D. DiFrancesco(357)
Department of Physiology and General Biochemistry, University of Milan, 20133 Milan, Italy
Department of Physiology, University of South Alabama, College of Medicine, Mobile, Alabama 36688
Milou D. Drici(1097)
Institut de Pharmacologie Moléculaire et Cellulaire, Sophia Antipolis, 06560 Valbonne, France
Department of Physiology, Catholic University of Leuven, B-3000 Leuven, Belgium
Istvan Edes(447)
Department of Heart and Lung Diseases, University Medical School, HU-4032 Debrecen, Hungary
Masao Endoh(609)
Department of Pharmacology, Yamagata University School of Medicine, Yamagata 990-9585, Japan
Denis Escande(1097)
Physiopathologie et Pharmacologie Cellulaires et Moléculaires, Hôpital G. R. Laennec, 44035 Nantes, France
Michael S. Forbes(71)
“Merry Oaks,” Troy, Virginia 22974
Akikazu Fujita(281)
Department of Veterinary Pharmacology, Faculty of Agriculture, University of Osaka Prefecture, Osaka 599-8531, Japan
Tetsushi Furukawa(389)
Department of Physiology I, Akita University School of Medicine, Akita 010-8543, Japan
A. Marquis Gacy(437)
Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic and Foundation, Rochester, Minnesota 55905
Antony Galione(679)
Department of Pharmacology, Oxford University, Oxford OX1 3QT, England
S. David Gertz(967)
Department of Anatomy and Cell Biology, The Hebrew University, Hadassah Medical School, Jersualem 91120, Israel
Augustus O. Grant(837)
Duke University Medical Center, Durham, North Carolina 27710
University of Western Ontario, Ontario, Canada
Christopher D. Hardin(571)
Department of Physiology, University of Missouri, Columbia, Missouri 65212
Robert D. Harvey(373)
Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio 44106
Armin Haunstetter(927)
Department of Cardiology, University of Heidelberg, Heidelberg, Germany
D.J. Hearse(887)
Cardiovascular Research, King’s Centre for Cardiovascular Biology and Medicine, The Rayne Institute, King’s College, St. Thomas’ Hospital, London SE1 7EH, England
Yuji Hirano(389)
Department of Cardiovascular Diseases, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 113-8510, Japan
Masayasu Hiraoka(389)
Department of Cardiovascular Diseases, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 113-8510, Japan
Franz Hofmann(247)
Institut für Pharmakologie und Toxikologie, Technische Universität München, D-80802 München, Germany
Masatsugu Hori(853)
Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita 565-0871, Japan
Steven R. Houser(1087)
Molecular and Cellular Cardiology Laboratory, Cardiovascular Research Group, Temple University School of Medicine, Philadelphia, Pennsylvania 19140
Joseph R. Hume(373)
Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, Nevada 89557
Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215
Arshad Jahangir(829)
Division of Cardiovascular Diseases and Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minnesota 55905
Aleksandar Jovanovic(693)
Tayside Institute of Child Health, Ninewells Hospital and Medical School, University of Dundee, Dundee,...
| Erscheint lt. Verlag | 9.10.2000 |
|---|---|
| Mitarbeit |
Chef-Herausgeber: Nicholas Sperelakis |
| Sprache | englisch |
| Themenwelt | Medizin / Pharmazie ► Allgemeines / Lexika |
| Medizinische Fachgebiete ► Innere Medizin ► Kardiologie / Angiologie | |
| Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie | |
| Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie | |
| Studium ► 2. Studienabschnitt (Klinik) ► Pathologie | |
| Naturwissenschaften ► Biologie ► Zellbiologie | |
| Naturwissenschaften ► Biologie ► Zoologie | |
| Technik | |
| ISBN-10 | 0-08-053388-4 / 0080533884 |
| ISBN-13 | 978-0-08-053388-9 / 9780080533889 |
| Haben Sie eine Frage zum Produkt? |
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