International Review of Cytology (eBook)

Cover 1
CONTENTS 6
CONTRIBUTORS 10
Chapter 1. The Nuclear Lamina and Its Functions in the Nucleus 12
I. Introduction 13
II. Building Blocks of the Nuclear Lamina 13
III. Structure of the Nuclear Lamina 24
IV. Dynamic Properties of Lamina Constituents during Mitosis 28
V. Roles of Nuclear Lamina 38
VI. Genetic Analyses of Lamina Genes 46
VII. Perspectives 55
References 56
Chapter 2. Genomic Domains and Regulatory Elements Operating at the Domain Level 74
I. Introduction 75
II. Locus Control Regions 77
III. Domain Boundaries and Insulators 100
IV. Strong and Weak Domains 112
V. DNA Replication Domains 116
VI. Concluding Remarks 120
References 122
Chapter 3. Membrane Dynamics and the Regulation of Epithelial Cell Polarity 138
I. Introduction 138
II. Structural Organization of Epithelial Cell Polarity 139
III. Regulation of Cell Polarity 144
IV. Membrane Transport in Epithelial Cells 149
V. Conclusions and Perspectives 164
References 165
Chapter 4. Growth During the Cell Cycle 176
I. Introduction 177
II. Models 179
III. Methods of Cell Cycle Analysis 182
IV. Mammalian Cells 191
V. Budding Yeast 197
VI. Fission Yeast 206
VII. Other Lower Eukaryotes 231
VIII. Prokaryotes 234
IX. Size Control 241
X. Summary 255
References 257
Chapter 5. Acidification and Protein Traffic 270
I. Introduction 270
II. Regulation of Organelle pH 274
III. Tools to Measure Organelle pH 280
IV. Methods to Perturb Organelle pH 284
V. Role of Acidification in Endocytic Membrane Traffic 291
VI. Acidification and the Secretory Pathway 300
VII. Concluding Remarks 310
References 312
Chapter 6. The Mannose Receptor in the Brain 332
I. Introduction 332
II. Mannose Receptor in the Brain 336
III. The Mannose Receptor in the Brain: The Hypotheses 343
IV. Concluding Remarks 346
References 347
Index 354