Health Research in Developing Countries (eBook)

Foreword 5
Preface 8
Contents 10
1 Introduction 14
1.1 HISTORY OF CRSN: from a project to an institution 14
1.2 Nouna DSS Data structure, data exchange and routine epidemiologic procedures 29
1.3 INDEPTH Network: Generating Empirical Population and Health Data in Resource-constrained Countries in the Developing World 32
1.4 Ethics of biomedical research in developing countries 43
1.5 Health Information Systems 53
2 Clinical Research 60
2.1 Overview 60
2.2 Effect of zinc supplementation on malaria and other causes of morbidity in west African children: randomised double blind placebo controlled trial 73
2.3 Evaluation of a prototype long-lasting insecticide- treated mosquito net under field conditions in rural Burkina Faso 80
2.4 Severe anaemia in west African children: malaria or malnutrition? 83
2.5 Clinical efficacy of chloroquine in young children with uncomplicated falciparum malaria – a community- based study in rural Burkina Faso 85
2.6 The association between protein-energy malnutrition, malaria morbidity and all- cause mortality in West African children 88
2.7 Effect of zinc supplementation on growth in West African children: a randomized double-blind placebo- controlled trial in rural Burkina Faso 94
2.8 Efficacy of pyrimethamine-sulfadoxine in young children with uncomplicated falciparum malaria in rural Burkina Faso 100
3 Epidemiological Studies 104
3.1 Introduction 104
3.2 Clustering of childhood mortality in rural Burkina Faso 110
3.3 Community factors associated with malaria prevention by mosquito nets: an exploratory study in rural Burkina Faso 119
3.4 Mortality patterns, 1993- 98, in a rural area of Burkina Faso, West Africa, based on the Nouna demographic surveillance system 129
3.5 Patterns of adult and old-age mortality in rural Burkina Faso 138
3.6 Malaria morbidity, treatment-seeking behaviour, and mortality in a cohort of young children in rural Burkina Faso 144
3.7 Risk factors of infant and child mortality in rural Burkina Faso 152
4 Health systems research 162
4.1 Introduction 162
4.2 Measuring the local burden of disease. A study of years of life lost in sub- Saharan Africa 163
4.3 Examining out-of-pocket expenditure on health care in Nouna, Burkina Faso: implications for health policy 172
4.4 Perceived quality of care of primary health care services in Burkina Faso 183
4.5 Informal risk-sharing arrangements (IRSAs) in rural Burkina Faso: lessons for the development of community- based insurance ( CBI) 191
4.7 Gender´s effect on willingness-to-pay for community- based insurance in Burkina Faso 219
4.8 A comparison of the reliability of the take-it- or- leave- it and the bidding game approaches to estimating willingness- to- pay in a rural population in West Africa 230
4.9 Willingness-to-pay for community-based health insurance in Burkina Faso 240
4.10 Differential willingness of household heads to pay community- based health insurance premia for themselves and other household members 255
4.11 The two faces of enhancing utilization of health- care services: determinants of patient initiation and retention in rural Burkina Faso 263
4.12 The feasibility of community-based health insurance in Burkina Faso 272
5 Biochemistry- based health care research 282
5.1 Introduction 282
5.2 Methylene blue as an antimalarial agent 290
5.3. Pharmacogenomic strategies against resistance development in microbial infections 295
Author index 299
Adresses of authors of chapters 301