Fetal Medicine

Part I: Cell, Molecular and Reproductive Biology.Early Concepts and Terminology. Genomic Imprinting. Staging Embryos in Development. Embryonic Tissues. Cellular Mechanisms in Development. Homebox Genes & Determination of Embryonic Body Plan. Embryology of Left-Right Defects of Situsin the Embryo. Development of the Head. Part II: Fetal and Placental Physiology. Implantation. Development of the Placenta and Its Circulation. Placental Function in Maternofetal Exchange. Fetal Growth and Its Control. Development of the Cardiovascular System. Kidney and Urinary Tract. Amniotic and Fetal Fluids. Lung Development and Maturation. Fetal Endocrinology. Blood and Immune System. Myometrial Physiology and Parturition. Maturation of the Brain and Behavioural States. The Response of the Fetal, Brain to Asphyxia/Ischaemia. Part III: Ethical Issues. Ethical Issues in Maternal-Fetal Medicine. Part IV: Epidemiology. Primary Prevention of Neural Tube Defects. Application of Epidemiology to Fetal Medicine. Assessing the Organisation and Effect of Perinatal Care. Adult Consequences of Fetal Disease. Fetal Malformation Registers. Part V: Prenatal Screening and Diagnosis. Genetic and Post-Pregnancy Counselling. The Stresses of Prenatal Screening and Diagnosis. Termination of Pregnancy: Methods, Safety and Recent Developments. Bereavement and Reaction to Fetal Loss. Screening for Genetic Disease in the Community. Biochemical Screening for Neural Tube Defects and Downs Syndrome. Ultrasound Screening for Fetal Abnormalities. Fetal Cells in the Maternal Circulation. Invasive Diagnostic Methods. Cytogenetics. DNA Analysis. Preimplantation Diagnosis. Transcervical Fetal Cells. Part VI: Diagnosis of Fetal Genetic Diseases. Haemoglobinopathies. Prenatal Diagnosis of Haemoglobinopathies and Other Inherited Coagulopathies. Cystic Fibrosis. Muscular Dystrophies. Inborn Errors of Metabolism. Genodermatoses. Part VII: Diagnosis and Management of Fetal Malformations. Second Trimester Sonographic Features of Aneuploidy. Fetal Nuchal Translucency at Weeks of Gestation. First Trimester Diagnosis of Fetal Malformations. Craniospinal and CNS Defects. Diagnosis and Management of Fetal Heart Disease. Thoracic Malformations. Kidney and Urinary Tract Disorders. Gastrointestinal Abnormalities. Skeletal Anomalies. Hydrops and Tumours. Operative Fetoscopy. Part VIII: Diagnosis and Management of Other Fetal Conditions. The Management of Intrauterian Growth Restriction. Red Cell Alloimmunisation. Diagnosis and Management of Fetal Platelet Disorders. Fetal Cardiac Arrhythmias. Fetal Endocrine Disorders. Early Pregnancy Loss. Fetal Infection. Twins and Polyhydramnios. Multifetal Pregnancy Reduction and Selective Fetocide. In Utero Haematopoietic Stem Cell Transplantation. Fetal Gene Therapy. Part IX: Methods of Fetal Monitoring.Antepartum Cardiotocography. Biophysical Profile. Fetal Biometry. Doppler Ultrasound. Day Assessment. Admission and Stimulation Tests in Labour. Intrapartum Fetal Monitoring. Other Methods of Monitoring in Labour. The Post Mortem Examination. Part X: The Neonate. Adaptation and Outcomes: The Neonatal Interface with Fetal Medicine. Cardiorespiratory Adaptation to Extrauterine Life. Thermal Adaptation to Extrauterine Life. Metabolic Adaptation to Extrauterine Life. Outcome in Children Contribution of Preterm Birth. Contribution of Perinatal Asphyxia in the Term Infant. Appendix. Growth Charts and Statistics.