Oxidative Stress in Heart Diseases (eBook)

Dr. Sajal Chakraborti (e.mail: saj_chakra@rediffmail.com) is a senior Professor of Biochemistry at the University of Kalyani, West Bengal, India. His research mainly focuses on the role of vasoactive agents in regulating vascular tone under oxidant and calcium signaling phenomena. He has been engaged in biochemistry teaching and research for the past 40 years.

 Dr. Naranjan S Dhalla (e.mail: NSDhalla@sbrc.ca) is a distinguished Professor at the University of Manitoba, Winnnipeg, Canada. His expertise includes the subcellular and molecular basis of heart function in health and disease. He has been involved in multidisciplinary research and education to promote the scientific basis of cardiology for over 50 years. 

Dr. Madhu Dixit (e.mail: rmadhudikshit@gmail.com) is a National Chair Fellow of the Translational Health Science and Technology Institute, Faridabad, Haryana, India. She has contributed to the general area of biochemical pharmacology and has a special interest in cardiovascular pharmacology, particularly redox biology.  Dr. Dikshit has been involved in research, especially drug discovery and development, for over 40 years.

Dr. Nirmal K Gangul, (e-mail: ganguly1nk@gmail.com), is a distinguished biotechnologist and former Director General of the Indian Council of Medical Research (ICMR), and is associated with Global Health Strategies, New Delhi, India. He was presented with the Padma Bhushan Award in the field of Medicine by the President of India in 2008.

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This book bridges the gap between fundamental and translational research in the area of heart disease. It describes a multidisciplinary approach, and demonstrates biochemical mechanisms associated with dysregulation of redox signaling, which leads heart disease. Presenting recent  studies on improved forms of ROS scavenging enzymes; specific inhibitors for different ROS generating enzymes; and oxidant induced signaling pathways and their antagonists that allow subtle modulation of redox signaling,  it also discusses the spatial and temporal aspects of oxidative stress in the cardiovascular system, which are of vital importance in developing better strategies for treating heart disease. Each chapter offers researchers valuable insights into identifying targets for drug development for different types of heart disease.