Asthma and COPD -  Peter J. Barnes,  Jeffrey M. Drazen,  Stephen I. Rennard,  Neil C. Thomson

Asthma and COPD (eBook)

Basic Mechanisms and Clinical Management
eBook Download: PDF
2002 | 1. Auflage
780 Seiten
Elsevier Science (Verlag)
978-0-08-048835-6 (ISBN)
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Chronic obstructive pulmonary disease (COPD), which encompasses both chronic bronchitis and emphysema, is one of the most common respiratory conditions of adults in the developed world. Asthma and COPD: Basic Mechanisms and Clinical Management provides a unique, authoritative comparison of asthma and COPD. Written and edited by the world's leading experts, it is a comprehensive review of the most recent understanding of the basic mechanisms of both conditions, specifically comparing their etiology, pathogenesis, and treatments.

* Highlights distinguishing features between asthma and COPD
* Reviews benefits and limitations of current therapies
* Summarises key information in two-colour artwork
* Extensively referenced to primary literature
Chronic obstructive pulmonary disease (COPD), which encompasses both chronic bronchitis and emphysema, is one of the most common respiratory conditions of adults in the developed world. Asthma and COPD: Basic Mechanisms and Clinical Management provides a unique, authoritative comparison of asthma and COPD. Written and edited by the world's leading experts, it is a comprehensive review of the most recent understanding of the basic mechanisms of both conditions, specifically comparing their etiology, pathogenesis, and treatments.* Highlights distinguishing features between asthma and COPD* Reviews benefits and limitations of current therapies* Summarises key information in two-colour artwork * Extensively referenced to primary literature

Cover 1
Contents 6
Foreword 10
Contributors 12
Preface 22
Dedication 24
Part I: Definitions, Epidemiology, and Genetics of Asthma and COPD 26
Chapter 1. Definitions 28
Chapter 2. Epidemiology 32
Chapter 3. Natural History 44
Chapter 4. Genetics 54
Part II: Physiology and Pathology of Asthma and COPD 66
Chapter 5. Pulmonary Physiology 68
Chapter 6. Airway Pathology 82
Chapter 7. Airway Remodeling 92
Chapter 8. Animal Models 104
Part III: Inflammatory Cells and Extracellular Matrix 114
Chapter 9. Mast Cells and Basophils 116
Chapter 10. Macrophages 124
Chapter 11. Eosinophils 136
Chapter 12. Lymphocytes 144
Chapter 13. Neutrophils 156
Chapter 14. Fibroblasts 164
Chapter 15. Epithelial Cells 170
Chapter 16. Mucus and Mucin-Secreting Cells 180
Chapter 17. Airway Smooth Muscle 190
Chapter 18. Tracheobronchial Circulation 202
Chapter 19. Pulmonary Vessels 208
Chapter 20. Plasma Exudation 220
Chapter 21. Cell Adhesion Molecules 228
Chapter 22. Extracellular Matrix 236
Part IV: Inflammatory Mediators and Pathways 244
Chapter 23. Prostanoids 246
Chapter 24. Leukotrienes 252
Chapter 25. Kinins 262
Chapter 26. Reactive Oxygen Species 268
Chapter 27. Chemokines 280
Chapter 28. Cytokines 286
Chapter 29. Matrix Degrading Proteinases 298
Chapter 30. Growth Factors 308
Chapter 31. Other Mediators of Airway Disease 316
Chapter 32. Nitric Oxide 332
Chapter 33. Transcription Factors 340
Chapter 34. Neural and Humoral Control 348
Part V: Pathogenic Mechanisms in Asthma and COPD 366
Chapter 35. Pathophysiology of Asthma 368
Chapter 36. Pathogenesis of COPD 386
Part VI: Triggers of Asthma and COPD 406
Chapter 37. Allergens 408
Chapter 38. Occupational Agents 420
Chapter 39. Infections 432
Chapter 40. Exercise as a Trigger 446
Chapter 41. Atmospheric Pollutants 456
Chapter 42. Drugs 464
Part VII: Clinical Assessment of Asthma and COPD 470
Chapter 43. Diagnosis 472
Chapter 44. Non-invasive Assessment of Airway Inflammation 482
Chapter 45. Imaging 490
Chapter 46. Assessment of Disability 506
Part VIII: Therapies for Asthma and COPD 512
Chapter 47. Allergen Avoidance 514
Chapter 48. Smoking Cessation 534
Chapter 49. ß2-adrenoceptor Agonists 546
Chapter 50. Anticholinergic Bronchodilators 552
Chapter 51. Theophylline 560
Chapter 52. Corticosteroids 572
Chapter 53. Mediator Antagonists 590
Chapter 54. Antibiotics 598
Chapter 55. Long-term Oxygen Therapy 612
Chapter 56. Immunomodulators 624
Chapter 57. Pulmonary Vasodilators 630
Chapter 58. Ventilator Support 636
Chapter 59. Pulmonary Rehabilitation 642
Chapter 60. Surgery 652
Chapter 61. Other Therapies 658
Chapter 62. Future Therapies 666
Chapter 63. Health Economics 682
Part IX: Clinical Management of Asthma and COPD 698
Chapter 64. Management of Chronic Asthma in Adults 700
Chapter 65. Acute Exacerbations of Asthma 714
Chapter 66. Childhood Asthma 724
Chapter 67. Treatment for Stable COPD 738
Chapter 68. Acute Exacerbations of COPD 752
Chapter 69. Education and Self-Management 762
Index 768

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