Asthma and COPD

Peter Barnes is Professor of Thoracic Medicine at the National Heart and Lung Institute, Head of Respiratory Medicine at Imperial College and Honorary Consultant Physician at Royal Brompton Hospital, London. He qualified at Cambridge and Oxford Universities was appointed to his present post in 1987. He has published over 1000 peer-review papers on asthma, COPD and related topics and has edited over 40 books. He is also amongst the top 50 most highly cited researchers in the world and has been the most highly cited clinical scientist in the UK and the most highly cited respiratory researcher in the world over the last 20 years. He was elected a Fellow of the Royal Society in 2007, the first respiratory researcher for over 150 years. He is currently a member of the Scientific Committee of the WHO/NIH global guidelines on asthma (GINA) and COPD (GOLD). He also serves on the Editorial Board of over 30 journals and is currently an Associate Editor of Chest and respiratory Editor of PLoS Medicine. He has given several prestigious lectures, including the Amberson Lecture at the American Thoracic Society and the Sadoul Lecture at the European Respiratory Society. Jeffrey M. Drazen, MD, was born in St. Louis, Missouri. He graduated from Tufts University with a major in physics, and from Harvard Medical School. He served his medical internship and residency at Peter Bent Brigham Hospital in Boston and was a clinical fellow and research fellow at Harvard Medical School and Harvard School of Public Health. Thereafter, he joined the Pulmonary Divisions of the Harvard hospitals and served for many years as chief of the combined Pulmonary Divisions at Beth Israel and Brigham and Women’s Hospitals. Currently, he is a Senior Physician at the Brigham and Women’s Hospital, and the Distinguished Parker B. Francis Professor of Medicine at Harvard Medical School, as well as Professor of Physiology, Harvard School of Public Health and adjunct Professor of Medicine at Boston University School of Medicine. He has served on the NIH Respiratory and Applied Physiology Study Section, the NIH Pulmonary Disease Advisory Council, the NIH Lung Biology and Pathology Study Section, and the NHLBI Advisory Council. Through his research, he defined the role of novel endogenous chemical agents in asthma. This led to four new licensed pharmaceuticals for asthma used in the treatment of millions of people worldwide. He has published nearly 500 papers and edited 6 books. He has been a member of the editorial boards of many prestigious journals, including: the Journal of Applied Physiology, American Journal of Physiology, Pulmonary Pharmacology, Experimental Lung Research, Journal of Clinical Investigation, American Journal of Respiratory Cell and Molecular Biology, and the American Journal of Medicine. In addition, he has been associate editor of the Journal of Clinical Investigation and the American Review of Respiratory Disease. In 2000, he assumed the post of editor-in-chief of the New England Journal of Medicine. During his tenure, the Journal has published major papers advancing the science of medicine. Neil Thomson is Professor of Respiratory Medicine at the University of Glasgow, Head of Respiratory Medicine within the Division of Immunology, Infection & Inflammation and Honorary Consultant at Gartnavel General Hospital, Glasgow. He graduated from the University of Glasgow and undertook postgraduate training in Glasgow, London and McMaster University, Canada. He is a former member of the Committee for Safety of Medicine and former Chair of the Scientific Committee of the British Lung Foundation. He has co-edited several textbooks on asthma and COPD and published over 150 peer-reviewed papers on asthma. His current research interests include corticosteroid insensitivity in smokers with asthma, biomarkers in asthma and COPD and assessment of novel treatments for asthma.

Contents
Foreword
Contributors
Preface
Dedication
Part I: Definitions, Epidemiology, and Genetics of Asthma and COPD
1 Definitions
2 Epidemiology
3 Natural History
4 Genetics
Part II: Physiology and Pathology of Asthma and COPD
5 Pulmonary Physiology
6 Airway Pathology
7 Airway Remodeling
8 Animal Models
Part III: Inflammatory Cells and Extracellular Matrix
9 Mast Cells and Basophils
10 Macrophages
11 Eosinophils
12 Lymphocytes
13 Neutrophils
14 Fibroblasts
15 Epithelial Cells
16 Mucus and Mucin-Secreting Cells
17 Airway Smooth Muscle
18 Tracheobronchial Circulation
19 Pulmonary Vessels
20 Plasma Exudation
21 Cell Adhesion Molecules,
22 Extracellular Matrix
Part IV: Inflammatory Mediators and Pathways
23 Prostanoids
24 Leukotrienes
25 Kinins
26 Reactive Oxygen Species
27 Chemokines
28 Cytokines
29 Matrix Degrading Proteinases
30 Growth Factors
31 Other Mediators of Airway Disease
32 Nitric Oxide
33 Transcription Factors
34 Neural and Humoral Control
Part V: Pathogenic Mechanisms in Asthma and COPD
35 Pathophysiology of Asthma
36 Pathogenesis of COPD
Part VI: Triggers of Asthma and COPD
37 Allergens
38 Occupational Agents
39 Infections
40 Exercise as a Trigger
41 Atmospheric Pollutants
42 Drugs
Part VII: Clinical Assessment of Asthma and COPD
43 Diagnosis
44 Non-invasive Assessment of Airway Inflammation
45 Imaging
46 Assessment of Disability
Part VIII: Therapies for Asthma and COPD
47 Allergen Avoidance
48 Smoking Cessation
49 b2-adrenoceptor Agonists
50 Anticholinergic Bronchodilators
51 Theophylline
52 Corticosteroids
53 Mediator Antagonists
54 Antibiotics
55 Long-term Oxygen Therapy
56 Immunomodulators
57 Pulmonary Vasodilators
58 Ventilator Support
59 Pulmonary Rehabilitation
60 Surgery
61 Other Therapies
62 Future Therapies
63 Health Economics
Part IX: Clinical Management of Asthma and COPD
64 Management of Chronic Asthma in Adults
65 Acute Exacerbations of Asthma
66 Childhood Asthma
67 Treatment for Stable COPD
68 Acute Exacerbations of COPD
69 Education and Self-Management
Index