Science & Technology on Public Health in China: A Roadmap to 2050 (eBook)

Foreword to the Roadmaps 2050 6
Preface to the Roadmaps 2050 12
Preface 17
Table of Contents 19
Abstract 22
1 Trends and National Needs of China’s Public Health 24
1.1 Current Status and Characteristic on China’s Public Health 24
1.1.1 Population Pressure and Ageing Society 24
1.1.2 Reproductive Health Faces Challenges 25
1.1.3 Nutrition-related Health and Food Safety Issues Becoming Increasingly Important 25
1.1.4 Disease Spectrum has been Changed 26
1.1.5 Infectious Diseases Remain a Serious Challenge 26
1.2 Influence of the Modern Science and Technology and the Trends on Public Health 27
1.2.1 Impact of Modern Science and Technology on Public Health 27
1.2.3 Transformation of Biomedicine 29
1.3 The Needs of China’s Public Health 29
1.3.1 The Needs on Improving China’s Innovative Ability in Biomedicine 30
1.3.2 The Needs on Controlling Population and Improving Birth Quality 30
1.3.3 The Needs on Public Health and Physical-mental Health 30
1.3.4 The Needs on Guaranteeing Biological and Food Safety 31
1.3.5 The Needs on Developing Modern Medical Industry 31
2 Overview of the China’s S& T Roadmap on Public Health to 2050
2.1 General Strategies of the Roadmap 33
2.2 Overview of the Roadmap 35
3 Biomedical Innovative System 36
3.1 Goals 36
3.2 Tasks 37
3.3 Technologies 37
3.3.1 Frontier Technologies of Life Science Relating to Public Health 37
3.3.2 Technology of Systems Biology 40
3.3.3 New Materials and New Formulations in the Biomedicine Field 40
3.3.4 Technology of Synthetic Biology 41
3.3.5 Animal Model Used for Research on Human Diseases 41
3.3.6 Nano-biomedical Technology 42
3.3.7 Database of Biomedical Resource and Data 42
3.3.8 Virtual Clinical and Health Research Network 42
3.4 Roadmap 43
4 Population Control and Reproductive Health 44
4.1 Goals 44
4.2 Tasks 45
4.3 Technologies 45
4.3.1 New Types of Contraceptive Technology 45
4.3.2 Cryopreservation and Thawing Technology of Reproductive Tissues/cells 46
4.3.3 oocyte/embryo in vitro Culture and Transfer Technology 46
4.3.4 Clinical Auxiliary Reproductive Technology Based on Micromanipulation 47
4.3.5 Genetic Diagnosis Before Embryo Implantation 47
4.3.6 Safety Appraisal for ART 47
4.3.7 Genetic Diagnosis and Correction Technology for Birth Defects 47
4.3.8 Screening Technology for Major Pregnancy-related Diseases and Reproductive Tract Disorders 48
4.4 Roadmap 48
5 Nutrition and Food Safety 49
5.1 Goals 49
5.2 Tasks 50
5.3 Technologies 51
5.3.1 Longitudinal Study and Platform for Research in Nutrition, Genetics and Health 51
5.3.2 Research Platforms and Related Technologies on Human Nutrition and Metabolism 51
5.3.3 Public-based Nutrition Surveillance and Education Network with Modern Information Technology 52
5.3.4 Genotype Based-dietary Patterns and Nutritional Recommendation 52
5.3.5 Detection Technique of Hazardous Food Substance and Research for the Underlying Mechanisms 52
5.3.6 Food Safety Risk Assessment and Early Warning Technologies 53
5.4 Roadmap 53
6 Chronic Non-communicable Disease Control and Healthcare Management 55
6.1 Goals 56
6.2 Tasks 57
6.3 Technologies 57
6.3.1 Technology and Methodology Based on Systems Biology for Research on the Mechanisms of Chronic Non-communicable Diseases 57
6.3.2 Technology for Uncovering the Molecular Biomarkers in Monitoring Dynamic Changes of the Health Status and Incidence or Progress of the Chronic Diseases 58
6.3.3 Technology and Methodology for Prevention and Intervention of the Chronic Diseases 58
6.3.4 Evaluation Models and Methodology of the Healthcare Management Fitting to the Characteristics of Chinese People 58
6.4 Roadmap 59
7 Infectious Diseases Prevention and Control 60
7.1 Goals 60
7.2 Tasks 61
7.3 Technologies 62
7.3.1 High-level Biosafety Laboratory System and Related Technologies 62
7.3.2 Efficient Screening System and Diagnostic Techniques 62
7.3.3 Animal Models for Important Infectious Pathogens 62
7.3.4 Key Technology in the Studies on Infection Mechanism for Important Pathogens 62
7.3.5 New Technologies for the Development of Drugs and Vaccines 63
7.3.6 Clinical Patient Typing Technology Against Infectious Diseases 63
7.4 Roadmap 64
8 Cognitive Neuroscience and Mental Health 65
8.1 Goals 65
8.2 Tasks 67
8.3 Technologies 67
8.3.1 In vivo Neuron Molecular Markers and Brain Function Imaging Technology 67
8.3.2 Brain Structure and Function Database for the Chinese Population 67
8.3.3 Basic Psychological Characteristics Database for the Chinese Population 68
8.3.4 Individualized Diagnosis Model for Cognitive, Psychological and Mental Disorders 68
8.3.5 Integrated Experimentation Techniques 68
8.3.6 Brain Elasticity Regulation Technology 68
8.3.7 Virtual Reality Technology 69
8.4 Roadmap 69
9 Innivative Drugs and Biomedical Engineering 70
9.1 Goals 71
9.2 Tasks 72
9.3 Technologies 73
9.3.1 Drug Discovery Technology 73
9.3.2 Innovation Technology Based on Network Pharmacology 73
9.3.3 Technology in Personalized Drug Discovery 73
9.3.4 Drug Development Technology Based on Stem-cell 73
9.3.5 Drug Safety Technology 74
9.3.6 Technology in Drug Release System and Formulation 74
9.3.7 Technology in TCM research 74
9.3.8 Large-scale Biological Manufacturing Technology 75
9.3.9 Technology in Biomaterials 75
9.3.10 Biomedical Engineering Technology 75
9.3.11 Technology in Resource Integration 75
9.4 Roadmap 76
10 Regenerative Medicine 77
10.1 Goals 77
10.2 Tasks 79
10.3 Technologies 79
10.3.1 Somatic Cell Reprogramming Technology 79
10.3.2 Animal Somatic Cell Cloning Technology 80
10.3.3 Embryonic Stem Cell Technology 80
10.3.4 Adult Stem Cell Technology 81
10.3.5 Tissue Engineering Technology 81
10.3.6 Organogenesis Technology 81
10.3.7 Evaluation Techniques for Safety and Efficacy of Transplantation 82
10.4 Roadmap 83
References 84