Experimental Hematology Today

I. Characterization of the Multipotential Stem Cell (CFU-s).- 1. The Appearance of the Multipotential Hemopoietic Stem Cell.- The spleen colony assay of rat HSC.- Concentration and identification of rat HSC.- Summary.- Acknowledgments.- References.- 2. An Immunologic Approach to Cell Cycle Analysis of the Stem Cell.- Materials and methods.- Results.- Discussion.- Summary.- Acknowledgments.- References.- 3. Physical Separation of the Cycling and Noncycling Compartments of Murine Hemopoietic Stem Cells.- Theory.- Materials and methods.- Results and discussion.- Summary.- Acknowledgments.- References.- 4. Characterization of Bone Marrow and Lymph Node Repopulating Cells by Transplanting Mononuclear Cells into Radiated Dogs.- Experimental approach.- Results.- Discussion.- Summary.- Acknowledgments.- References.- II. Humoral and Cellular Control Agents.- 5. Concepts and Observations on the Regulation of Granulocyte Production.- Materials and methods.- Results.- Summary.- Acknowledgment.- References.- 6. The Regulatory Role of the Macrophage in Normal and Neoplastic Hemopoiesis.- Materials and methods.- Results.- Discussion.- Summary.- Acknowledgments.- References.- 7. Humoral Regulation of Eosinophil Granulocytopoiesis.- Eosinophil granulocytopoiesis: A model system.- Production of humoral factor(s) in vitro.- Summary.- Acknowledgments.- References.- 8. Studies of the Erythroid Inductive Microenvironment in Vitro.- Materials and methods.- Results.- Discussion.- Summary.- Acknowledgments.- References.- 9. In Vivo Colony Forming Unit Population Sizes in Hypertransfused Sl/Sld Mice.- Methods.- Results.- Discussion.- Summary.- References.- III. Physiology of Committed Stem Cells (CFU-e and CFU-m).- 10. Recognition of Hemopoietic Progenitors.- Summary.- References.- 11. Relationships between Early Hemopoietic Progenitor Cells Determined by Correlation Analysis of Their Numbers in Individual Spleen Colonies.- Experimental.- Results.- Discussion.- Summary.- Acknowledgments.- References.- 12. Some Characteristics of in Vitro Erythroid Colony and Burst-Forming Units.- Methods and materials.- Results.- Discussion.- Summary.- Acknowledgments.- References.- 13. Colony-Forming Unit, Megakaryocyte (CFU-m): Its Use in Elucidating the Kinetics and Humoral Control of the Megakaryocytic Committed Progenitor Cell Compartment.- Materials and methods.- Results.- Discussion.- Summary.- Acknowledgment.- References.- IV. Physiology of Committed Stem Cells (CFU-c).- 14. Negative and Positive Feedback Control of the Committed Granulocytic Stem Cell Compartment.- Physiologic control of the CFU-c.- Positive feedback system for CFU-c regulation.- Negative feedback system for CFU-c control.- Possible interaction of the two feedback systems in the regulation of the CFU-c compartment.- Summary.- References.- 15. Colony-Stimulating Factor and the Differentiation of Granulocytes and Macrophages.- Materials and methods.- Results.- Discussion.- Summary.- Acknowledgments.- References.- 16. Characteristics of the in Vitro Monocyte-Macrophage Colony-Forming Cells Detected within Mouse Thymus and Lymph Nodes.- Materials and methods.- Results.- Discussion.- Summary.- Acknowledgments.- References.- 17. Physical Characterization of a Subpopulation of Granulocyte/Monocyte Progenitor Cells (CFU-c).- Materials and methods.- Results.- Discussion.- Summary.- Acknowledgments.- References.- 18. Cell-Factor Interaction in Populations of Normal and Leukemic Blood Cells.- Results.- Discussion.- Summary.- Acknowledgments.- References.- V. Bone Marrow Transplantation Immunology.- 19. Bone Marrow Transplantation Immunology.- Summary.- Acknowledgments.- References.- 20. Modulation of Graft-versus-Host (GvH) Disease in the Rat; Effect of Hydroxyurea on the Mixed Lymphocyte Reaction and Graft-versus-Host Reactivity.- Materials and methods.- Results.- Discussion.- Summary.- Acknowledgments.- References.- 21. Mechanism of Donor to Host Tolerance in Rat Bone Marrow Chimeras.- Materials and methods.- Results.- Discussion.- Summary.- Acknowledgment.- References.- 22. Effects of a Cell-Free Helper Factor(s) on the Kinetics of T-Cell Responses to Histocompatibility Antigens.- Materials and methods.- Results.- Discussion.- Summary.- Acknowledgment.- References.- VI. Experimental Models of Clinical Conditions in Hematology.- 23. The E(AkR)-Leukemia as Murine Model of Human Acute Lymphoid Leukemia for Immunotherapy Trials.- Summary.- References.- 24. Experimental Chemotherapy: A Rat Model for Human Acute Myeloid Leukemia.- Materials and methods.- Results.- Discussion.- Summary.- Acknowledgments.- References.- 25. Serum Colony Stimulating Factor: A Marker for Graft-versus-Host Disease in Humans.- Methods.- Results.- Discussion.- Summary.- Acknowledgments.- Appendix: Case histories.- References.- 26. Changes in Human Bone Marrow Colony-Forming Cells following Chemotherapy Using an Agar Diffusion-Chamber Technique.- Methods.- Results.- Discussion.- Summary.- Acknowledgments.- References.- 27. Graft-versus-Leukemia, Donor Selection for Adoptive Immunotherapy in Mice.- Materials and methods.- Results.- Discussion.- Summary.- Acknowledgments.- References.