Future Directions in Biocatalysis

Tomoko Matsuda is an Associate Professor at the School of Life Science and Technology, Tokyo Institute of Technology. For 20 years, her research has been focused on the organic synthesis with enzymes, biocatalysis, and particularly the study of enzymatic reactions in a non-aqueous solvent. Her group has achieved the waste-minimization in large-scale production of chiral compounds with a flow system using liquid and supercritical carbon dioxide as a solvent and an immobilized lipase as a catalyst.

Novel Reaction Conditions for Biotransformation
1. Biotransformation in ionic liquid (Toshiyuki Itoh).
2. Temperature Control of the Enantioselectivity in the Lipase-catalyzed Resolutions (Takashi Sakai).
3. Future Directions in Photosynthetic Organisms-catalyzed Reactions (Kaoru Nakamura).
4. Catalysis by Enzyme-Metal Combinations (Mahn-Joo Kim et al.).

Uncommon Kind of Biocatalytic Reaction
5. Biological Kolbe-Schmitt Carboxylation of Possible use of enzymes for the direct carboxylation of organic substrates (Toyokazu Yoshida, Toru Nagasawa).
6. Discovery, redesign and applications of Baeyer-Villiger monooxygenases (D.E. Torres Pazmiño, M.W. Fraaije).
7. Enzymes in aldoxime-nitrile pathway: versatile tools in biocatalysis (Yasuhisa Asano).
8. Addition of Hydrocyanic Acid to Carbonyl Compounds (Franz Effenberger et al.).

Novel Compound Synthesized by Biotransformation
9. Chiral Heteroatom-Containing Compounds (P. Kielbasinski, M. Mikolajczyk).
10. Enzymatic Polymerization (Hiroshi Uyama).
11. Synthesis of Naturally Occurring beta-D-Glucopyranosides Based on Enzymatic beta-Glucosidation using beta-Glucosidase from Almond (Hiroyuki Akita).

Use of Molecular Biology Technique to Find Novel Biocatalyst
12. Future Directions in Alcohol Dehydrogenase-Catalyzed Reactions (J.D. Stewart).
13. Enzymatic Decarboxylation of Synthetic Compounds
(K. Miyamoto, Hiromichi Ohta).