The Mitochondrion in the Germline and Early Development

Section I. The mitochondrion and gametes
Chapter 1
The role of the mitochondrion in sperm function. Is there a place for oxidative phosphorylation or is this a purely glycolytic process?
Chapter 2
The role of mitochondrial function in the oocyte and embryo
Chapter 3
Mitochondrial DNA in the Oocyte and the developing embryo

Section II. Transmission
Chapter 4
Mitochondrial DNA and the mammalian oocyte
Chapter 5
Mitochondrial disease - its impact, aetiology and pathology
Chapter 6
Cybrid models of mtDNA disease and transmission, from cells to mice

Section III. The use of ARTs to regulate mtDNA disease.
Chapter 7
The use of Micromanipulation Methods as a Tool to Prevention of Transmission of Mutated Mitochondrial DNA
Chapter 8
Difficulties and possible solutions in the Genetic Management of mtDNA disease in the pre-implantation embryo

Section IV. The effects of invasive ARTs on mtDNA transmission
Chapter 9
Impact of assisted reproductive techniques: a mitochondrial perspective from the cytoplasmic transplantion
Chapter 10
Nuclear Transfer – preservation of a nuclear genome at the expense of its associated mtDNA genome(s)