Novartis Foundation Symposium 235 – Ageing Vulnerability – Causes and Interventions

Iminosugars may be regarded as glycomimetics, alkaloids, natural products or as potential drugs. This book should therefore interest academic and industrial researchers in various areas such as organic synthesis, carbohydrate chemistry, medicinal chemistry, biochemistry, biotechnology, biology and medical sciences.

Introduction (T. Kirkwood). The Priority of Basic Research on Ageing Vulnerability in a Comprehensive Research Agenda on Ageing for the 21st Century (G. Andrews). Do Alterations in Glutathione and Iron Levels Contribute to Pathology Associated with Parkinson's Disease? (J. Andersen). Specific Metal-Catalysed Protein Oxidation Reactions in Chronic Degenerative Disorders of Ageing: Focus on Alzheimer's Disease and Age-Related Cataracts (A. Bush & L. Goldstein). General Discussion I: The Role of Glial Cells in the Ageing Brain. Multiple Substrates of Late-Onset Dementia: Implications for Brain Protection (R. Kalaria, et al.). Ageing of Murine Small Intestinal Stem Cells (C. Potten, et al.). Haematopoietic Stem Cell Ageing (A. Globerson). General Discussion II. Identification of Genes Involved in Cell Senescence and Immortalization: Potential Implications for Tissue Ageing (J. Leung & O. Pereira-Smith). Ageing and Cancer: The Telomere and Telomerase Connection (J. Shay & W. Wright). Ageing and the Immune System (R. Effros). General Discussion III. Mechanisms of Age-Related Bone Loss (L. Mosekilde). The Old Heart: Operating on the Edge (E. Lakatta, et al.). Pharmaceutical Intervention of Advanced Glycation Endproducts (A. Cerami & P. Ulrich). General Discussion IV. The Anti-Ageing Action of Dietary Restriction (H. Van Remmen, et al.). Mitochondrial DNA Mutations in Disease and Ageing (D. Cottrell). A Mitochondrial Paradigm for Degenerative Diseases and Ageing (D. Wallace). Final Discussion. Index of Contributors. Subject Index.