Ageing Vulnerability

The Novartis Foundation is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research.

Symposium on Ageing vulnerability: causes and interventions, held at the Novartis Foundation,
London, 29 February^3 March 2000

Editors: Gregory Bock (Organizer) and Jamie A. Goode

This symposium is based on a proposal made by Gary Andrews. It was organized as a key component and in support of the United Nations Project ‘A Research Agenda on Ageing for the 21st Century’
Thomas B. L. Kirkwood Introduction 1

Gary R. Andrews The priority of basic research on ageing vulnerability in a comprehensive research agenda on ageing for the 21st century 4

Discussion 9

Julie K. Andersen Do alterations in glutathione and iron levels contribute to pathology associated with Parkinson’s disease? 11

Discussion 20

Ashley I. Bush and Lee E. Goldstein Specific metal-catalysed protein oxidation reactions in chronic degenerative disorders of ageing: focus on Alzheimer’s disease and age-related cataracts 26

Discussion 38

General discussion I The role of glial cells in the ageing brain 44
R.N. Kalaria, C.G. Ballard, P.G. Ince, R.A. Kenny, I.G. McKeith, C.M. Morris, J.T. O’Brien, E. K. Perry, R.H. Perry and J. A. Edwardson Multiple substrates of late-onset dementia: implications for brain protection 49

Discussion 60

C. S. Potten, K. Martin and T. B. L. Kirkwood Ageing of murine small intestinal stem cells 66

Discussion 79

Amiela Globerson Haematopoietic stem cell ageing 85

Discussion 96

General discussion II 101

James K. Leung and Olivia M. Pereira-Smith Identification of genes involved in cell senescence and immortalization: potential implications for tissue ageing 105

Discussion 110

Jerry W. Shay and Woodring E.Wright Ageing and cancer: the telomere and telomerase connection 116

Discussion 125

Rita B. E¡ros Ageing and the immune system 130

Discussion 139

General discussion III 146

Lis Mosekilde Mechanisms of age-related bone loss 150

Discussion 166

Edward G. Lakatta, Steven J. Sollott and Salvatore Pepe The old heart: operating on the edge 172

Discussion 196

Anthony Cerami and Peter Ulrich Pharmaceutical intervention of advanced glycation end products 202

Discussion 212

General discussion IV 217

Holly Van Remmen, Zhongmao Guo and Arlan Richardson The anti-ageing action of dietary restriction 221

Discussion 230

D. A. Cottrell, E. L. Blakely, M. A. Johnson, G.M. Borthwick, P. I. Ince and D. M. Turnbull Mitochondrial DNA mutations in disease and ageing 234

Discussion 243

Douglas C. Wallace A mitochondrial paradigm for degenerative diseases and ageing 247

Discussion 263

Final discussion 267

Index of contributors 273

Subject index 275