Mechanobiology

Boris Martinac – Head of Mechanosensory Biophysics Laboratory at the Victor Chang Cardiac Research Institute – is an experimental biophysicist who is renowned for his discovery of mechanosensitive channels in bacteria and his pioneering contributions to the new field of mechanobiology. He majored in physics and received his PhD degree in biophysics from the RWTH Aachen University in Germany. He has published >200 peer-reviewed journal papers. Notably, the Nobel Prize Assembly recently highlighted Prof Martinac’s ground-breaking work in proving the existence of mechanosensitive channels which led to the 2021 Nobel Prize for Physiology or Medicine. His contributions to the research in the mechanotransduction field have been recognised by numerous honours and awards, including election to the Fellowship of the Australian Academy of Science in 2013 as well as election to the Fellowship of the US Biophysical Society in 2023. At the Victor Chang Cardiac Research Institute his workexpanded into studies of the role mechanosensitive ion channels play in cardiac health and disease.Charles D. Cox - Head of the Cardiac Mechanobiology Laboratory at the Victor Chang Cardiac Research Institute - is a qualified pharmacist who practiced in both hospital and community settings (2008-2013) prior to joining the Victor Chang Cardiac Research Institute. He completed his PhD in 2013, following on from a Master’s degree (Honours 1st class) in Pharmacy; both at Cardiff University, UK. Dr Cox’s over-arching research interest is in understanding the molecular mechanisms and pathways by which physical forces are sensed by cells. In particular his research has contributed to understanding how ion channels sense and respond to these signals within the cardiovascular system and how they integrate mechanical signals in both health and disease. In 2015 Dr Cox was awarded the Young Biophysicist of the Year Award from the Australian Society of Biophysics and received a prestigious New South Wales Health EMCR Fellowship to support his work (2019-2021). Following this in 2022 Dr Cox was awarded an Australian Research Council Future Fellowship (2023-2026) and appointed as a laboratory Head of the Cardiac Mechanobiology Lab at the Victor Chang Cardiac Research Institute. Kate Poole - Head of the Cellular Mechanotransduction laboratory at UNSW, is a physiologist and biophysicist studying the role of force sensing in human physiology. After a PhD in microbial biotechnology, awarded by the University of Adelaide, she joined the emerging field of research in mechanobiology. Her early work in the field contributed to the development of imaging and force-spectroscopy approaches using atomic force microscopy. Subsequently, her research has focused on the characterization and identification of mammalian mechanosensitive ion channels, particularly in touch transduction and in cancer. She was the first person awarded the Cecile Vogt Fellowship and has won multiple grants to support her mechanobiology research from funders in Australia, Germany, and the USA. She has a strong commitment to helping the development of young scientists as they begin their careers in research and dedicates a substantial proportion of her time to teaching both undergraduate and postgraduate students about aspects of biological force sensing, and its role in human health and disease.     Sara Baratchi - Alice Baker and Eleanor Shaw Gender Equity Fellow and Lab Head at the Baker Heart and Diabetes Research Institute is also an Associate Professor in the Baker Department of Cardiometabolic Health at the University of Melbourne. Her research is centered around pioneering artificial models of human blood vessels and heart valves, utilizing advanced microfabrication and microfluidic technologies. These models provide a platform for systematically elucidating the molecular mechanisms that regulate cellular responses to hemodynamic forces. The organ-on-a-chip models offer distinct advantages in advancing vascular biology at both basic and applied levels. They also play a crucial role in screening novel therapeutics for cardiovascular and metabolic disorders. This interdisciplinary work necessitates close collaboration with engineers, vascular biologists, immunologists, bioinformaticians, and clinicians. Dr Baratchi’s contributions to the field include publishing more than 64 papers in high-impact biomedical and bioengineering journals. Notably, she has led first or senior-author publications in Circulation, Cellular and Molecular Life Sciences, Cellular Physiology, Lab on a Chip, Analytical Chemistry, ACS Applied Materials & Interfaces, Biosensors & Bioelectronics, and Small and her research has received over 3,117 citations, with an h-index of 29 (Google Scholar). Her achievements have been recognized through several nationally competitive grants, awards, and fellowships including grants from the National Health and Medical Research Council (2020197), Australian Research Council (DE170100239, LP190100728, DP200101248), the 2023 Alice Baker and Eleanor Shaw Gender Equity Fellowship and the 2015 RMIT Vice-Chancellor's Fellowship. Daryan Kempe is an early-career postdoctoral research fellow in the Cell motility and mechanobiology group and a lecturer at UNSW Sydney. After completing his PhD in single-molecule biophysics with summa cum laude at RWTH Aachen University, Germany, Daryan transitioned into the field of mechano-immunology to study immune cell migration and cancer killing dynamics. To this end, he uses cutting-edge microscopy techniques, biophysical assays, and custom computational image analysis tools in combination with in vitro models mimicking the three-dimensional tumour micro-environment to unravel the environmental cues that impair immune cells effector functions. Daryan has published numerous articles in high tier journals including Developmental Cell (lead author), Analytical Chemistry (corresponding author), Nature Communications, Advanced Science and eLife. 

Chapter 1: Mechanically-evoked TRPV4-mediated currents are modulated by activated integrin beta1.- Chapter 2: Shear force activation of epithelial Na+ channel (ENaC) is modulated by N-glycans of the betaENaC subunit.- Chapter 3: Fueling biologically relevant next-generation microvasculature-on-a-chip platforms with mechanobiology.- Chapter 4: Using FRET to determine how Myo10 responds to force in filopodia.- Chapter 5: The Physical Factors Involved in Cancer Progression.- Chapter 6: The molecular basis of the Frank-Starling Law of the heart. Insights from the last 100 years.