Genome Editing for Neurodegenerative Diseases

Assistant Professor in Department of Medical Biotechnology at the All India Institute of Medical Sciences, Nagpur. He is researcher and neuroscientist with a strong background in Biochemistry and Biomedicine. His research interests are in neurodegenerative diseases and has ~12 years of experience. He’s a member of editorial boards of several international journals related to neuroscience and member of several scientific societies. Dr. Singh has been appointed as Bentham Ambassador by Bentham Science Publisher (USA). He is a speaker at several scientific national and international conferences/symposium/workshops in India and abroad. Dr. Amarish K Yadav is a postdoctoral research scholar at North Carolina State University. His current research interest is developing gene-drive systems using CRISPR/Cas9 in Drosophila suzukii. After obtaining his master’s degree in biotechnology, he was awarded his Ph.D. from Banaras Hindu University in 2017. He has worked in collaboration with many neuroscientists and researchers to understand the molecular mechanisms of Alzheimer’s and Parkinson’s diseases progression and therapeutics. Dr. Yadav has published his research findings in peer-reviewed journals and has also authored a book chapter on neurodegenerative diseases modeling in drosophila. Dr. Yadav has participated and presented his research work at various national and international conferences and symposia. Dr. Burkhard Poeggeler is affiliated with the Georg-August-University Göttingen and works primarily on the biochemistry and pharmacology of regeneration by antioxidant protection and trophic prosurvival signaling. His research focusses on bioenergetic agents such as nitric oxide and on redox regulation such as neurovascular coupling. Together with many other distinguished scientists he investigates the unique nootropic, neurotrophic and neuroprotective activity of melatonin and related tryptophan metabolites based on their potent antioxidant, anti-inflammatory antiamyloidogenic effects such as amyloid clearance by the glymphatic system, the connective tissue, the interstitium and the gastrointestinal tract. Based on the exploration of these protective agents, he works on developing new possibilities to extend human health and life span. He is widely published with over 120 PubMed listed publications. Dr. George Perry, Ph.D. Professor of Biology and Chemistry Semmes Foundation Distinguished University Chair in Neurobiology He is a neuroscientist known for his work on neuronal oxidation of nucleic acids in Alzheimer's disease. He is distinguished as one of the top Alzheimer’s disease researchers with over 1000 publications, won numerous awards, and is one of the top 100 most-cited scientists.

Introduction Burkhard Poeggeler 1. Therapeutic potential of genome editing tools in neurodegenerative diseases Ankur Kumar, Nandigam Pardhipa, Sachin G. Swami, Vibha Dwivedi and Anand K. Singh 2. Genetic and molecular basis of neurodegenerative diseases Sunanda Yogi, Anjali Sangeeth, Anuradha Venkatakrishnan Chimata, Radhika Padma and Amit Singh 3. Genome editing tools: principles, structures, and mechanisms Rayees Ahmad Naik, Mehak Naseer Mir, Roshni Rajpoot, Sonalika Singh, Kusum Singh and Sandeep Kumar Singh 4. Advances in CRISPER/Cas system and genome editing technologies for the treatment of neurodegenerative diseases Shailendra Kumar Mishra, Hung-Ming Chang, Ahmad A. Obaid and Sandeep Kumar Singh 5. Use of CRISPR system in genetic screening to detect neurodegenerative disease Koyel Kar 6. Epigenetic manipulation and gene regulation using the CRISPR/Cas system for neurodegenerative diseases Josephine Esposto 7. Transgene delivery system: viral, nonviral, and other methods for central nervous system Bhupender Sahu, Bibhudendu Behera and Umesh Kumar 8. Gene therapies for neurodegenerative disease: current knowledge and challenges Bhumi Arora, Sakshi Garg, Aditya Shrivastav, Mrinalini Sharma, Bhupender Sahu and Umesh Kumar 9. Gene therapy under clinical trials for neurodegenerative diseases Bhupender Sahu, Lakshita Tyagi, Prshant Tyagi and Umesh Kumar 10. Clinical challenges and future prospective in use of gene-editing tools as neurotherapeutics Burkhard Poeggeler