Schizophrenia

A Novel Method to Estimate Levels of Receptors Using an Allosteric Modulator. Focus on muscarinic M1 receptors.- Enhanced bystander BRET (ebBRET) biosensors as biophysical tools to map the signaling profile of neuropsychiatric drugs targeting GPCR.- [35S]GTPγS (Guanosine-5′-O-(γ-thio)triphosphate-[35S]) Binding Scintillation Proximity Assay experiments in postmortem brain tissue.- CRISPR/Cas9 as a simple technique for the generation of murine knockout models for neuropsychiatric diseasesEvaluation of sensory-motor gating deficits in mice th.- rough prepulse inhibition (PPI) of the startle response.- Automated detection of psychedelic-induced head twitch response in mice.- Gastrointestinal and microbiome profiling in rodent models of neurological and psychiatric disorders.- Electroencephalography for the study of the auditory P300 evoked potential and derived measurements.- Quantification of endocannabinoids in human plasma.- Neuropsychological and functional assessment of cognitive impairments in schizophrenia.- Clinical management and assessment of the early stages of psychosis: a multidimensional approach.