Cell-Penetrating Peptides (eBook)

Prof. Makoto Oba received his Ph.D. degree in pharmaceutical sciences from Kyushu University in 2004. He joined the faculty of the University of Tokyo (2004-2010) and Nagasaki University (2010-2020). He moved to Kyoto Prefectural University of Medicine on 2020 as full Professor at Graduate School of Medicine. He has authored over 100 scientific publications and has received several awards, including the Pharmaceutical Society of Japan Award for Young Scientists (2013), Nagasaki Prefectural Science and Technology Award for Young Scientists (2016), and the Incentive Award in Synthetic Organic Chemistry (2019). Dr. Yosuke Demizu received his Ph.D. in pharmaceutical sciences from Kyushu University in 2006. He joined the faculty of Tokushima Bunri University (2004-2005) and then at Nagasaki University (2006-2008). He moved to the National Institute of Health Sciences (NIHS) as a researcher, and was promoted to head the division of organic chemistry in 2017. He has authored over 150 scientific publications and has received several awards, including the Incentive Award in Synthetic Organic Chemistry, Japan (2006, 2010) and the Award for Young Investigators from the Japanese Peptide Society (2014).

Introduction

PART 1: DESGIN OF CPPS
Classification of cell-penetrating peptides
Arginine-rich cell-penetrating peptides: recent advances of design and applications for intracellular delivery
Cationic cell-penetrating peptides
Amphipathic cell-penetrating peptides
Hydrophobic cell-penetrating peptides
Foldamers

PART 2: MECHANISM OF CPPS
Peptide Structure: Electrophysiological analysis, nuclear magnetic resonance analysis, and molecular dynamics simulation of direct penetration of cell-penetrating peptides through bilayer lipid membranes
Cellular uptake mechanisms of arginine-rich cell-penetrating peptides
Endosomal escape
Pharmacokinetics of therapeutic and diagnostic agents conjugated with cell-penetrating peptides

PART 3: DELIVERY TOOLS
Drug delivery
Peptide & protein delivery
Cell-penetrating peptides for nucleic acid delivery
PPMOs: a case study for cell-penetrating peptide application
Cell penetrating peptide-conjugated polymer micelles for pDNA/siRNA delivery
Lipid-based nanoparticles using cell-penetrating peptides

PART 4: APPLICATIONS
Cell-penetrating peptides as tools to facilitate oral delivery of biopharmaceuticals
Intranasal delivery
Clinical trials
Applications in plants