Handbook of the Biology of Aging

Edward J. Masoro was the recipient of the 1989 Allied-Signal Achievement Award in Aging Research. In 1990, he received the Geriatric Leadership Academic Award from the National Institute on Aging and the Robert W. Kleemeier Award from the Gerontological Society of America. In 1991, he received a medal of honor from the University of Pisa for Achievements in Gerontology. In 1993, Dr. Masoro received the Distinguished Service Award from the Association of Chairmen of Departments of Physiology. He received the 1995 Irving Wright Award of Distinction of the American Federation for Aging Research and the 1995 Glenn Foundation Award. He served as the President of the Gerontological Society of America from 1994–1995, as the Chairman of the Aging Review Committee of the National Institute on Aging (NIA), and as Chairman of the Board of Scientific Counselors of the NIA. Dr. Masoro received his Ph.D. from the University of California at Berkeley. He has held faculty positions at Queens University (Canada), Tufts University School of Medicine, University of Washington,and Medical College of Pennsylvania. From 1973 through May 1991, he served as Chairman of the Department of Physiology at the University of Texas Health Science Center at San Antonio. He presently continues his duties as Professor in the Department of Physiology and is the Director of the newly created Aging Research and Education Center. On April 1, 1996, he became Professor Emeritus. Dr. Masoro was a Wellcome Visiting Professor in Basic Medical Sciences for the 1992–1993 Academic Year. His research has been in lipid metabolism, cold exposure, membrane biochemistry, and biological gerontology. Since 1975, Dr. Masoros research has focused on the influence of food restriction on aging. He has or is serving in an editorial role for ten journals, and in January 1992, he became the Editor of the Journal of Gerontology: Biological Sciences.

HANDBOOK OF THE BIOLOGY OF AGING, 6e

Edited by Edward J. Masoro and Steve Austad

Section I: Conceptual and Technical Issues

Chapter 1
Reliability Theory of Aging and Longevity
Leonid A. Gavrilov and Natalia S. Gavrilova

Chapter 2 - Are Age-Associated Diseases an Integral Part of Aging?
Edward J. Masoro

Chapter 3 - Dietary Restriction, Hormesis and Small Molecule Mimetics
David A. Sinclair and Konrad T. Howitz

Chapter 4 - Hematopoietic Stem Cells, Aging, and Cancer
Deborah Bell and Gary Van Zant

Chapter 5 - Mitochondria: A Critical Role in Aging
Tamara Golden, Karl Morten, Felicity Johnson, Enrique Samper, and Simon Melov

Chapter 6 - P53 and Mouse Aging Models
Cathy Gatza, George Hinkal, Lynette Moore, Melissa Dumble, and Lawrence A. Donehower

Chapter 7 - Complex Genetic Architecture of Drosophila Longevity
Trudy Mackay, Natalia V. Roshina, Jeff W. Leips, and Elena G. Pasyukova

Chapter 8 - Evolutionary Biology of Aging: Future Directions
Daniel Promislow, Ken Fedorka, and Joep Burger

Chapter 9 - Senescence in Wild Populations of Mammals and Birds
Anja Brunet-Rossini and Steven N. Austad

Chapter 10 - Biodemography of Aging and Age-Specific Mortality in Drosophila melanogaster
James Curtsinger, Natalia S. Gavrilova, and Leonid A. Gavrilov

Chapter 11 - Microarray Analysis of Gene Expression Changes in Aging
F. Noel Hudson, Matt Kaeberlein, Nancy Linford, David Pritchard, Richard Beyer, and Peter S. Rabinovitch

Chapter 12 - Computer Modeling in the Study of Aging
Thomas Kirkwood, Richard Boys, Colin Gillespie, Carole Procter, Daryl Shanley, and Darren Wilkenson

Section II: Non-Mammalian Models

Chapter 13 - Dissecting the Processes of Aging Using the Nematode Caenorhabditis elegans
Thomas E. Johnson, Samuel T. Henderson, Shane Rea

Chapter 14 - Genetic Manipulation of Life span in Drosophila. Melanogaster
Daniel Ford and John Tower

Chapter 15 - Juvenile and Steroid Hormones in Drosophila melanogaster Longevity
Meng-Ping Tu, Thomas Flatt,, Marc Tatar

Chapter 16 - A Critical Evaluation of Nonmammalian Models for Aging Research
Steven N. Austad, Andrej Podlutsky

Section III: Mammalian Models

Chapter 17 - Differential Aging Among Skeletal Muscles
Roger J. M. McCarter

Chapter 18 - Aging, Body Fat, and Carbohydrate Metabolism
Marielisa Rincon, Radhika Muzumdar, and Nir Barzilai

Chapter 19 - Growth and Aging: Why do Big Dogs Die young?
Richard Miller and Steven N. Austad

Chapter 20 - Growth Hormone, Insulin-Like Growth Factor-1 and the Biology of Aging
Christy S. Carter and William E. Sonntag

Chapter 21 - Aging of the Female Reproductive System
Phyllis Wise