Handbook of the Biology of Aging

Edward J. Masoro was the recipient of the 1989 Allied-Signal Achievement Award in Aging Research. In 1990, he received the Geriatric Leadership Academic Award from the National Institute on Aging and the Robert W. Kleemeier Award from the Gerontological Society of America. In 1991, he received a medal of honor from the University of Pisa for Achievements in Gerontology. In 1993, Dr. Masoro received the Distinguished Service Award from the Association of Chairmen of Departments of Physiology. He received the 1995 Irving Wright Award of Distinction of the American Federation for Aging Research and the 1995 Glenn Foundation Award. He served as the President of the Gerontological Society of America from 1994–1995, as the Chairman of the Aging Review Committee of the National Institute on Aging (NIA), and as Chairman of the Board of Scientific Counselors of the NIA. Dr. Masoro received his Ph.D. from the University of California at Berkeley. He has held faculty positions at Queens University (Canada), Tufts University School of Medicine, University of Washington,and Medical College of Pennsylvania. From 1973 through May 1991, he served as Chairman of the Department of Physiology at the University of Texas Health Science Center at San Antonio. He presently continues his duties as Professor in the Department of Physiology and is the Director of the newly created Aging Research and Education Center. On April 1, 1996, he became Professor Emeritus. Dr. Masoro was a Wellcome Visiting Professor in Basic Medical Sciences for the 1992–1993 Academic Year. His research has been in lipid metabolism, cold exposure, membrane biochemistry, and biological gerontology. Since 1975, Dr. Masoros research has focused on the influence of food restriction on aging. He has or is serving in an editorial role for ten journals, and in January 1992, he became the Editor of the Journal of Gerontology: Biological Sciences.

Part I: Basic Aging Processes

1. The Genetic Network of Lifespan Extension by Dietary Restriction - Eric Greer and Anne Brunet

2. Role of the Somatotropic Axis in Mammalian Aging - Holly M.Brown-Borg

3. Mechanisms of Mitochondrial Free Radical Production and their Relationship to the Aging Process - Casey L. Quinlan, Jason R. Treberg, and Martin D. Brand

4. Aging and Apoptosis in Muscle - Stephen E. Alway, Michael R. Morissette, and Parco M. Siu

5. Aging and Adipose Tissue - Roberta Florido, Tamara Tchkonia, and James L. Kirkland

6. Aging of Stem Cells: Intrinsic Changes and Environmental Influences - Ling Liu and Thomas A. Rando

7. Leukocyte Telomere Dynamics, Human Aging and Lifespan - Abraham Aviv

8. An Unbiased Appraisal of the Free Radical Theory of Aging - Michael Lustgarten, Florian L. Muller, and Holly Van Remmen

9. TOR: A Conserved Nutrient-Sensing Pathway that Determines Life-Span Across Species - Pankaj Kapahi and Lutz Kockel

10. Comparative Genetics of Aging - George L. Sutphin and Matt Kaeberlein

11. Sirtuins in Aging and Age-Related Diseases - Marcia C. Haigis and David A. Sinclair

12. Inflammation in Aging Processes: An Integrative and Ecological Perspective - Caleb E. Finch

13. Protein Homeostasis and Aging - Susmita Kaushik and Ana Maria Cuervo

Part II: Medical Physiology of Aging

14. Terminal Weight Loss, Frailty, and Mortality - Edward J. Masoro

15. Human Brain Myelination Trajectories Across the Lifespan: Implications for CNS Function and Dysfunction - Jonathan E. Sherin and George Bartzokis

16. Aging and the Cerebral Microvasculature: Clinical Implications and Potential Therapeutic Interventions - Farzaneh A. Sorond and Lewis A. Lipsitz

17. Aging and Insulin Secretion - Jeffrey B. Halter

18. Cardiovascular Effects of Aging in Primates - Gender Differences - Hongyu Qiu, Christophe Depre, Dorothy E. Vatner, and Stephen F. Vatner

19. Cerebral Vascular Dysfunction with Aging - Frank M. Faraci

20. Pulmonary Function in Aging Humans - Nigel A.S. Taylor

21. Calorie Restriction in Nonhuman and Human Primates - Luigi Fontana, Ricki J. Colman, John O. Holloszy, and Richard Weindruch

22. Age-related Changes in Thermoreception and Thermoregulation - Eus J.W. Van Someren

23. Sex Differences in Longevity and Aging - Steven N. Austad