Mutation Detection
Oxford University Press (Verlag)
978-0-19-854888-1 (ISBN)
- Titel ist leider vergriffen;
keine Neuauflage - Artikel merken
Cancer and the mechanisms of its development are receiving increasing research interest. New genes are being isolated almost daily. Fundamental to those studies is the ability to detect mutations. Mutation detection is time consuming and expensive and thus, should be undertaken with a thorough knowledge of the alternative methods. This book aims to critically review the field, refer to methodology and protocols and give illustrative examples as well as put the whole emerging field in context including ethics.
1.: Introduction. 2.: Sequencing Methods. 3.: Scanning Methods. 3.1: Physical Methods. 3.1.1.: Denaturing Gradient Gel Electrophoresis. 3.1.2.: Single Strand Conformational Polymorphism. 3.1.3.: Heteroduplex. 3.2.: Mismatch Detection/Cleavage. 3.2.1.: Ribonuclease. 3.2.2.: Chemical Cleavage. 3.2.3.: Carbodiimide. 3.2.3.: DNA endonucleases and binding proteins. 3.3.: Other. 4.1.: Allele Specific Oligonucleotide. 4.2.: Ligase and LCR. 4.3.: Allele Specific Amplification. 4.4.: Primer Extension. 4.5.: Artificial Introduction of Restriction Sites. 4.6.: Restriction Enzymes. 5.: Associated Methodology. 5.1.: Southern Blots. 5.2.: PCR. n 5.3.Illegitimate Transcription. 5.4.: Gene Specific Strategies. 6.: Current Weaknesses and Future Requirements
| Erscheint lt. Verlag | 30.11.1996 |
|---|---|
| Zusatzinfo | bibliography |
| Verlagsort | Oxford |
| Sprache | englisch |
| Maße | 150 x 230 mm |
| Gewicht | 510 g |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Laboratoriumsmedizin |
| Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie | |
| Studium ► 2. Studienabschnitt (Klinik) ► Anamnese / Körperliche Untersuchung | |
| Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik | |
| Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie | |
| ISBN-10 | 0-19-854888-5 / 0198548885 |
| ISBN-13 | 978-0-19-854888-1 / 9780198548881 |
| Zustand | Neuware |
| Haben Sie eine Frage zum Produkt? |
aus dem Bereich
